Effects of Telmisartan Bisoprolol Combined with Trimetazidine on Plasma BNP and Fg Levels and Cardiopulmonary Function in Patients with COPD Complicated with CHD
DAI Kefen, YU Qian, WANG Wenjing, et al
Chengdu Third People's Hospital,Sichuan Chengdu 610000,China
Abstract：Objective: To explore the effects of telmisartan,bisoprolol combined with trimetazidine on plasma B-type natriuretic peptide (BNP) and fibrinogen (Fg) levels and cardiopulmonary function in patients with chronic obstructive pulmonary disease (COPD) complicated with coronary heart disease (CHD).Methods: 164 patients with COPD and CHD admitted to our hospital from March 2014 to March 2019 were selected,numbered according to the order of admission and randomly divided into study group and control group by sealed envelope method.82 cases in study group were given telmisartan + bisoprolol,and 82 cases in control group were treated with telmisartan,bisoprolol+trimetazidine.The changes of lung function indexes,cardiac function indexes,plasma BNP and Fg levels and serum inflammatory related indexes were compared between the two groups.Results: After treatment,the PEF,FVC and FEV1/FVC were significantly increased in the two groups (P<0.05),and the increases in study group were higher than those in control group (P<0.05).The LVEF in the two groups was significantly increased (P<0.05) while the LVEDD and LVESD were significantly decreased (P<0.05),and the changes in study group were greater than those in control group (P<0.05).The plasma BNP and Fg levels were significantly decreased in the two groups (P<0.05),and the decreases in study group were greater compared with those in control group.The serum levels of NF-κB,Chemerin,TGF-β and MMP-9 were significantly decreased in the two groups (P<0.05),and the decreases in study group were greater than those in control group (P<0.05).Conclusion: Telmisartan,bisoprolol combined with trimetazidine has exact efficacy in the treatment of COPD with CHD,and can significantly improve cardiopulmonary function,reduce plasma BNP and Fg levels,and inhibit synthetic release of serum NF-κB,Chemerin,TGF-β and MMP-9,and reduce the body’ s inflammatory damage.
戴克芬, 余倩, 王文婧, 杨晓兰, 汪艳丽. 替米沙坦比索洛尔联合曲美他嗪治疗对慢性阻塞性肺疾病合并冠心病患者血浆BNP Fg水平及心肺功能的影响[J]. 河北医学, 2020, 26(11): 1805-1809.
DAI Kefen, YU Qian, WANG Wenjing, et al. Effects of Telmisartan Bisoprolol Combined with Trimetazidine on Plasma BNP and Fg Levels and Cardiopulmonary Function in Patients with COPD Complicated with CHD. HeBei Med, 2020, 26(11): 1805-1809.
2020, Vol. 26 
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