HSP70 TNF-α IL-4 与妊娠期高血压患者体液免疫的关系研究

doi:10.3969/j.issn.1006-6233.2020.11.04

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摘要 目的: 分析热休克70kDa蛋白(HSP70)、肿瘤坏死因子-α(TNF-α)、白细胞介素-4(IL-4)与妊娠期高血压患者体液免疫的关系。方法: 选取2016年12月至2019年6月108例医院收治妊娠期高血压患者作为观察组,并选取同时期108例正常妊娠孕妇作为对照组,观察两组患者体液免疫指标以及血清HSP70、TNF-α、IL-4差异,并分析HSP70、TNF-α、IL-4与妊娠期高血压患者体液免疫的相关性。结果: 观察组与对照组的C3、C4、IgA、IgG、IgM等体液免疫指标间的比较差异有统计学意义(P<0.05);观察组与对照组的血清HSP70、TNF-α和IL-4水平差异有统计学意义(P<0.05);通过相关性分析发现,HSP70、TNF-α、IL-4与妊娠期高血压患者体液免疫存在正相关性(均P<0.05)。结论: 妊娠期高血压患者体液免疫水平与HSP70、TNF-α、IL-4存在正相关性,可以通过HSP70、TNF-α、IL-4检查筛查高危孕妇,从而尽早给予有效的干预措施,保护母婴健康安全。

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	王影
	洪海漫
	孟斐

关键词 ： 70kDa蛋白, 肿瘤坏死因子-α, 白细胞介素-4, 妊娠期高血压, 体液免疫

Abstract：Objective: To analyze the relationship between heat shock 70 KDa protein (HSP70),tumor necrosis factor-α(tnf-),interleukin-4(IL-4) and humoral immunity in hypertensive patients during pregnancy.Methods: 108 patients with gestational hypertension treated in hospitals from December 2016 to June 2019 were selected as observation group,and 108 pregnant women in the same period,the control group.Observe the humoral immune indexes and serum HSP70,TNF-α,IL-4 differences between the two groups,and to analyze the correlation between HSP70,TNF-α,IL-4 and humoral immunity in hypertensive patients during pregnancy.Results: There was significant difference in humoral immunity between observation group and control group (P<0.05).There was significant difference in serum HSP70,TNF-α and IL-4 levels between the observation group and the control group (P<0.05).The correlation analysis showed that there was a close correlation between HSP70,TNF-α,IL-4 and humoral immunity in patients with gestational hypertension (all P<0.05).Conclusion: There is a positive correlation between humoral immune level and HSP70,TNF-α,IL-4 in hypertensive patients during pregnancy,which can screen high-risk pregnant women through HSP70,TNF-α,IL-4 examination,so as to give effective intervention measures as soon as possible to protect the health and safety of mother and child.

Key words： HSP70 TNF-α IL-4 Gestational hypertension Humoral immunity

基金资助:辽宁省科学技术计划项目,(编号:2018225061)

引用本文:

王影, 洪海漫, 孟斐. HSP70 TNF-α IL-4 与妊娠期高血压患者体液免疫的关系研究[J]. 河北医学, 2020, 26(11): 1776-1779.
WANG Ying, HONG Haiman, MENG Fei. The Relationship Between HSP70 TNF-α IL-4 and Humoral Immunity of Hypertensive Patients During Pregnancy. HeBei Med, 2020, 26(11): 1776-1779.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2020.11.04 或 http://www.hbyxzzs.cn/CN/Y2020/V26/I11/1776