Abstract：Objective: To explore the efficacy of nasal endoscopic Messerklinger surgery on fungal rhinosinusitis (FRS) and its effects on serum level of inflammatory factors of patients.Methods: 116 patients with FRS admitted to our hospital from June 2017 to June 2019 were selected as the analysis subjects,and they were divided into observation group and control group with the simple random grouping method,with 58 cases in each group.The patients in control group were treated with traditional Caldwell-Luc surgery,and the patients in observation group were treated with nasal endoscopic Messerklinger surgery.The clinical efficacy of the two groups was compared,and the incidence rates of postoperative complications (local infection,nasal mucosal redness,blood in the nose,facial numbness,toothache) were recorded.The levels of serum inflammatory factors [interleukin-6 (IL-6),interleukin-12 (IL-12),tumor necrosis factor-α (TNF-α)],eosinophil cationic protein (ECP) and total immunoglobulin E (TIgE) were observed in the two groups before surgery and at 1 month after surgery.Results: The total clinical effective rate in observation group was higher than that in control group (100.00% vs 93.10%) (P>0.05).The incidence rates of postoperative complications in observation group were significantly lower than those in control group (P<0.05).At 1 month after surgery,the levels of serum inflammatory factors IL-6,IL-12,TNF-α,ECP and TIgE in the two groups were significantly lower than those before surgery,and the levels in observation group were significantly lower than those in control group during the same period (P<0.05).Conclusion: Nasal endoscopic Messerklinger surgery has significant efficacy in treating FRS,and it can effectively reduce the incidence rates of postoperative complications,relieve the inflammation level,and reduce the serum ECP and TIgE levels.
王军利, 张滟, 何珍. 鼻内镜下Messerklinger手术治疗真菌性鼻-鼻窦炎疗效及对患者血清炎症因子水平的影响[J]. 河北医学, 2020, 26(11): 1761-1765.
WANG Junli, ZHANG Yan, et al. Efficacy of Nasal Endoscopic Messerklinger Surgery on Fungal Rhinosinusitis and Its Effects on Serum Level of Inflammatory Factors of Patients. HeBei Med, 2020, 26(11): 1761-1765.
2020, Vol. 26 
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