Abstract：Objective: To analyze the correlation between serum total immunoglobulin E(IgE), eosinophil cationic protein (ECP) and histamine release factor (HRF) and helicobacter pylori (Hp) infection in urticaria. Methods: 76 patients with urticaria were divided into mild group (13 cases), moderate group (38 cases) and severe group (25 cases) according to the severity of the disease. They were divided into Hp positive group (48 cases) and Hp negative group (28 cases) according to the Hp infection, at the same time, 68 healthy volunteers were collected as control group. The levels of total IgE, ECP and HRF in blood of each group were compared and correlation analysis was carried out. Results: The levels of serum total IgE, ECP and HRF in urticaria group were higher than those in control group (P<0.05). The levels of serum total IgE, ECP and HRF in severe urticaria group were higher than those in moderate group and mild group, and the serum total IgE, ECP and HRF levels in moderate group were higher than those in mild group (P<0.05). The levels of serum IgE, ECP, HRF and HP in HP positive urticaria group were higher than those in HP negative urticaria group (P<0.05). Pearson correlation analysis showed that serum total IgE, ECP, HRF levels were positively correlated with HP (P<0.05). Conclusion: Urticaria infection combined with HP infection can promote the expression of serum total IgE, ECP and HRF, and increase the severity of the disease.
孔德华, 黄玮, 赵桂苹, 程文婷. 慢性荨麻疹合并Hp感染患者血清总IgE ECP和HRF浓度的相关性分析[J]. 河北医学, 2020, 26(10): 1652-1655.
KONG Dehua, HUANG Wei, ZHAO Guiping, et al. Correlation Analysis of Serum Total IgE, ECP and HRF Concentrations in Patients with Chronic Urticaria Complicated with Hp Infection. HeBei Med, 2020, 26(10): 1652-1655.
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2020, Vol. 26 
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