Abstract：Objective: To study effect of TNF-α and interleukin(IL-18andIL-6)in patients with chronic obstructive pulmonary disease using anticoagulant drugs. Method: 94 patients were divided into two groups, 47 in each group. The conventional group used common therapy, and the anticoagulation group used anticoagulant drugs on the basis of the conventional group. Observe the following indicator changes. Results: The effective rate of COPD patients in the anticoagulation group was significantly higher than that in the conventional group(P＜0.05). There was no difference between the two groups before treatment (P > 0.05). After treatment, the levels of TNF - α, IL-18 and IL-6 in the two groups were significantly lower than those in the anticoagulant group (P < 0.05). The patients in the routine group and anticoagulant group had different degrees of ecchymosis, increased platelet count and other symptoms. The single ecchymosis disappeared by itself, and the platelet and coagulation time returned to the normal level. There was no difference between the two groups (P > 0.05). Conclusion: The expression of TNF - α, IL-18 and IL-6 in the serum of patients with COPD can be significantly inhibited by antitussive and expectorant drugs combined with anticoagulant therapy. The clinical effect of COPD is obviously improved, which is worth popularizing.
2020, Vol. 26 
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