Abstract：Objective: To evaluate the relationship between GINS expression levels and the prognosis of tumor patients used by meta-analysis. Methods: The articles about the relationship between the expression level of GINS and the prognosis of cancer patients in Wanfang medical network, VIP database and PubMed database were retrieved. The retrieval time was up to April 30, 2019, and the meta-analysis was carried out with Revman 5.3 software. Results: 7 articles including 722 patients included in the study about the relationship between GINS gene expression levels and overall survival (OS), the results showed high GINS gene expression of tumor patients significantly shortened OS (HR = 2.11, 95% CI 1.43 ~ 3.10, P = 0.0002);3 articles including 991 patients included in the study about the relationship between GINS gene expression levels and disease-free survival (DFS), the results showed high GINS gene expression of tumor patients significantly shortened DFS (HR = 1.60, 95% CI 1.38 ~ 1.86, P = 0.00001). Conclusion: The high expression of GINS gene has a certain relationship with the poor prognosis of tumor patients, suggesting that GINS may be a potential target for tumor prognosis.
王世博, 柳晓金, 郑立恒, 高艳军. GINS表达水平与肿瘤患者预后关系的meta分析[J]. 河北医学, 2020, 26(1): 80-83.
WANG Shibo, et al. Meta-analysis of the Relationship between the Expression Level of GINS and the Prognosis of Tumor Patients. HeBei Med, 2020, 26(1): 80-83.
[1] Douglas ME, Ali FA,Costa A, et a1.The mechanism of eukaryotic CMG helicase activation[J].Nature,2018,555(7695):265~268. [2] Joshi K, Shah VJ, Maddika S.GINS complex protein Sld5 recruits SIK1 to activate MCM helicase during DNA replication[J].Cell Signal,2016,28(12):1852~1862. [3] Fei Ouyang,Junling Liu, Meng Xia,et a1.GINS2 is a novel prognostic biomarker and promotes tumor progression in early-stage cervical cancer[J].Oncol Rep,2017,37(5): 2652~2662. [4] Kanzaki R, Naito H, Kise K,et al. PSF1 (Partner of SLD Five 1)is a prognostic biomarker in patients with non-small cell lung cancer treated with surgery following preoperative chemotherapy[J].Ann Surg Oncol,2016,23(12):4093~4100. [5] Ting Yan,Wentong Liang,Enli Jiang,et al.GINS2 regulates cell proliferation and apoptosis in human epithelial ovarian cancer[J].Oncol Lett,2018,16(2): 2591~2598. [6] Tauchi S,Sakai Y,SFujimoto S,et al. Psf3 is a prognostic biomarker in lung adenocarcinoma:a larger trial using tissue microarrays of 864 consecutive resections[J].Eur Cardiothorac Surg,2016,50(4):758~764.
2020, Vol. 26 
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