Abstract：Objective: To investigate the clinical efficacy and safety of docetaxel combined with irinotecan and irinotecan combined with teggio in patients with advanced gastric cancer. Methods: 35 patients with advanced gastric cancer receiving chemotherapy with docetaxel combined with tiggio in the department of oncology of our hospital between September 2013 and April 2018 were selected as the experimental group, and 25 patients receiving irinotecan combined with tiggio as the control group. The disease control rate and toxicity reaction after chemotherapy were compared between the two groups. The clinical value of docetaxel and irinotidine combined with teggio in patients with advanced gastric cancer were evaluated. Results: The tumor remission rate and control rate of the experimental group were 34.29% and 71.43%, respectively, while those of the control group were 36% and 72%. The difference between the two groups was not statistically significant (χ2=0.019, 0.002, P>0.05). After chemotherapy toxicity of two groups of reactions including leukopenia, thrombocytopenia, nausea and vomiting, hair loss, neurotoxicity, and extremities syndrome, etc., and all kinds of reaction is given priority to with 0 ~ Ⅱ degrees, differences were not statistically significant (P>0.05). Conclusion: Docetaxel combined with tegeor and irinotecan combined with tegeor can effectively control the development speed of cancer patients, reduce the occurrence of toxic reactions, and both of them have the same effect, and the patients with toxic reactions can tolerate, which is worthy of clinical application.
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2020, Vol. 26 
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