Abstract：Objectives: To study the relationship between autoimmune function and microecological changes in children with wheezing bronchitis. Methods: 140 children with wheezing bronchitis admitted to our hospital from July 2015 to April 2018 were selected as the object of this study, as the observation group and 125 children with normal physical examination in our hospital as the control group. The indexes of autoimmune function and microecology were observed in the two groups. The correlation analysis was used to analyze the correlation between immune function and microecological indexes. Results: The levels of CD3+, CD4+, CD4+/CD8+, NK and interferon gamma in the observation group were as follows: (52.57±2.05)%, (23.62±0.89)%, (1.25±0.2)%, (12.88±0.36%)%, (44.02±1.51)ng/L, It was significantly lower than the control group (67.86±2.89)%, (41.53±1.37)%, (1.86±0.26)%, (17.51±0.22)%, (58.2±1.72)ng/L. The difference was significant (P<0.05). The IL-4, IL-10 indicators are: (60.49±3.53)ng/L, (14.13±1.18)ng/L, It was significantly higher than that of the control group (28.74±1.73)ng/L, (5.89±0.92)ng/L. The difference was significant (P<0.05). In the observation group, Bifidobacterium and Lactobacillus were as follows: (4.33±0.97)lg CFU, (5.07±0.60)lg CFU. It was significantly lower than the control group. (9.33±0.76)lg CFU, (9.56±0.65)lg CFU, Escherichia coli and staphylococci are Escherichia coli and Staphylococcus, respectively: (7.06±0.49)lg CFU, (4.11±0.82)lg CFU, It was significantly higher than that of the control group.(4.87±0.68)lg CFU, (1.74±0.42)lg CFU. The difference was significant (P<0.05). The indexes of CD3, CD4 and NK, interferon gamma were positively correlated with Bifidobacillus and Lactobacillus, negatively correlated with Escherichia coli and Staphylococcus, and negatively correlated with Bifidobacillus and Lactobacillus, and positively correlated with Escherichia coli and Staphylococcus. Conclusion: The imbalance of immune function and intestinal microecological flora in children with wheezing bronchitis may affect each other and the whole process of the disease.
[1] 赵静.糜蛋白酶联合氨溴索对慢性支气管炎患者C反应蛋白,中性粒细胞的影响[J].山西医药杂志,2018,47(20):65~67. [2] Bian F, Wu Y, Zhang C L. Use of aerosol inhalation treatment with budesonide and terbutaline sulfate on acute pediatric asthmatic bronchitis:[J]. Experimental & Therapeutic Medicine, 2017, 14(2):1621~1625. [3] 张美霞,何浙海,曹伟银,等.不同类型病原体感染的喘息性疾病患儿治疗情况及预后分析[J].中医临床研究,2017,9(15):87~89. [4] 罗柳.肺炎支原体感染伴喘息患儿免疫功能变化的研究[J].中国现代医药杂志,2013,15(6):36~38. [5] Li J, Zhang Z Z, Lei Z H, et al. NMR based metabolomic comparison of the antitussive and expectorant effect of farfarae flos collected at different stages[J].Pharm Biomed Anal, 2018, 150:377~385. [6] 王彬,张盼盼,曹向可,等.补充益生菌对喘息性支气管炎患儿免疫和微生态变化的影响[J].中国综合临床,2018,34(2):109~114. [7] 孙丽,党纪红.布地奈德粉吸入剂联合异丙托溴铵对喘息性支气管炎患儿症状及肺功能的影响[J].河南医学研究,2018,27(18):100~101. [8] Song W J, Kim H J, Shim J S, et al. Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough-variant asthma and eosinophilic bronchitis in adults with chronic cough: A systematic review and meta-analysis[J]. Journal of Allergy & Clinical Immunology, 2017, 140(3):701~709. [9] 方戴琼,顾思岚,石鼎,等.人体肠道微生态与疾病发生发展的关系及机制研究进展[J].中国微生态学杂志,2016,28(5):614~617. [10] 朱思睿.高脂膳食诱导肠道菌群失调与认知功能损害关系研究进展[J].中国公共卫生,2018,34(3):453~457.
2020, Vol. 26 
冀公网安备13080202000786号