Abstract：Objective: To analyze the correlation between serum oxidized low density lipoprotein (oxidized low density lipoprotein, ox-LDL), interleukin-18 (IL-18), lipoprotein-associated phosphatase A2 (Lp-PLA2) and carotid atherosclerotic plaque in patients with cerebral infarction. Methods: 120 patients with cerebral infarction (study group) and 35 healthy volunteers (control group) who were admitted to the hospital from March 2018 to March 2019 were enrolled in the study. General data of both groups were collected. Serum ox-LDL, IL-18 and Lp-PLA2 levels were compared between the two groups. Carotid intima-media thickness (CIMT) and the maximum area of plaques were measured. Crouse score of carotid plaques was calculated. The correlation between serum ox-LDL, IL-18 and Lp-PLA2 levels and carotid atherosclerotic plaques was analyzed. Results: Serum ox-LDL, IL-18 and Lp-PLA2 levels, CIMT, the maximum area of plaques, Crouse score of carotid plaques in the study group were significantly higher than those of the control group (P<0.05). Correlation analysis showed that CIMT, the maximum area of plaques and Crouse score were positively correlated with serum ox-LDL, IL-18 and Lp-PLA2 levels (P<0.05). Conclusion: The changes of serum ox-LDL, IL-18 and Lp-PLA2 levels may be effective predictors of carotid atherosclerotic plaque formation in patients with cerebral infarction.
2020, Vol. 26 
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