Abstract：Objective: To investigate the expression of ENA polypeptide antibody spectrum in patients with autoimmune diseases and its correlation with T lymphocyte level. Methods: A total of 100 patients diagnosed with autoimmune diseases from November 2016 to November 2017 were selected as the study group, and 40 healthy medical personnel from our hospital during the same period were selected as the control group. The detection rate of ENA polypeptide antibody and the expression of T lymphocytes of the two groups were analyzed. Results: The positive rate of ENA polypeptide antibody was significant in the study group. At the same time, two or more autoantibodies were detected. The serum of the study group contained a variety of autoantibodies, indicating that the ENA antibody contained the corresponding disease antibody spectrum. Conclusion: Because of the clinical manifestations of autoimmune disease variety, increase the difficulty of early diagnosis, and the ENA polypeptide antibody detection repeatability, no special equipment, less YongXieLiang time, simple operation, good specificity, but also for a variety of autoantibodies to sieving and recognition at the same time, is beneficial to the patients with early diagnosis, is of great help to the follow-up treatment, worth clinical promotion.
孙喜明, 李佳, 高振奎. ENA多肽抗体谱在自身免疫性疾病患者中的表达及与T淋巴细胞水平的相关性研究[J]. 河北医学, 2019, 25(9): 1545-1549.
SUN Ximing, LI Jia, GAO Zhenkui, et al. Study on the Expression of ENA Polypeptide Antibody Spectrum in Patients with Autoimmune Diseases and its Correlation with T Lymphocyte Level. HeBei Med, 2019, 25(9): 1545-1549.
[1] 史国星,曾强,窦剑,等.CD4~+C25~+Foxp3~+调节性T细胞在自身免疫性疾病中的研究进展[J].免疫学杂志,2016,33(12):1092~1095. [1] 陶玉泉,刘志丹.中药复方对免疫性疾病中CD4~+CD(25)~+调节性T细胞的影响[J].中华中医药学刊,2016,26(3):592~596. [1] 李晞,郑乐婷,石昌荆,等.健康体检者筛查自身抗体的临床意义[J].广东医学,2019,40(01):117~119,123. [1] 林其德.重视自身免疫性疾病围产期管理[J].中国实用妇科与产科杂志,2016,32(10):921~923. [1] Rodr??Guez-Mu?±Oz A, Vitales-Noyola M, Ramos-Levi A, et al. Levels of regulatory T cells CD69(+)NKG2D(+)IL-10(+) are increased in patients with autoimmune thyroid disorders[J]. Endocrine, 2016, 51(3):478~489. [1] Chun S, Casparino A, Patsopoulos N A, et al. Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types[J]. Nature Genetics, 2017, 49(4):600~605. [1] 盖林林,管立学,李海波,等.免疫性疾病患者T-SPOT.TB筛查结果及影响因素[J].山东大学学报:医学版,2016,54(6):82~86. [1] 辛雪亭,杨春晓.自身免疫性疾病研究进展[J].中华神经医学杂志,2016,15(1):105~107. [1] 李光韬,张卓莉.自身免疫性疾病与发热[J].中国实用内科杂志,2016,36(12):1032~1035. [1] 温晓婷,李永哲.自身免疫病新自身抗体的筛选方法研究进展[J].中华风湿病学杂志,2016,37(1):59~62. [1] Eames H L, Corbin A L, Udalova I A. Interferon regulatory factor 5 in human autoimmunity and murine models of autoimmune disease[J]. Translational Research, 2016, 167(1):167~182. [1] 李和军,李频,林顺平,等.抗核抗体谱中阳性的自身抗体数目对狼疮诊断的意义[J].重庆医学,2018,16(2):200~202. [1] 高启健,向波,刘忠民.抗核抗体两种检测方法在系统性红斑狼疮中的诊断性能比较[J].实用医学杂志,2017,33(9):1498~1502. [1] Wangrenault S F, Boudaoud S, Nocturne G, et al. Deregulation of microRNA expression in purified T and B lymphocytes from patients with primary Sj?gren’s syndrome[J]. Annals of the Rheumatic Diseases, 2018, 77(1):133~140. [1] 段炤,林智平,刘青,等.CD4CD调节性T淋巴细胞与辅助性T淋巴细胞17在川崎病发病机制中的作用[J].中华实用儿科临床杂志,2017,32(9):652~655.
2019, Vol. 25 
冀公网安备13080202000677号