新生血管性青光眼患者房水和血浆中PlGF IL-1β和TGF-β<sub>2</sub>的测定及意义

doi:10.3969/j.issn.1006-6233.2019.09.027

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摘要 目的:检测新生血管性青光眼(NVG)患者房水和血浆中胎盘生长因子(PlGF)PlGF、白细胞介素-1β(IL-1β)、和转化生长因子(TGF-β2)水平,并分析房水和血浆中PlGF、IL-1β和TGF-β2水平的关系。方法:选取2016年4月至2018年9月本院确诊为NVG的患者42例,共42只眼,选取同期年龄相关性白内障(ARC)患者50例(50眼)作为对照组,采用酶联免疫吸附法(ELISA)检测房水和血清中PlGF、IL-1β和TGF-β2水平。结果:NVG组患者房水和血清中PlGF、IL-1β、TGF-β2水平显著高于ARC组患者(P<0.05);NVG组患者房水较血清中PlGF、TGF-β2水平显著升高(P<0.05);ARC组患者房水较血清中PlGF、TGF-β2水平无显著变化(P>0.05);两组患者房水较血清中IL-1β水平均显著升高(P<0.05)。经Pearson检验,NVG患者房水和血清中PlGF、IL-1β、TGF-β2水平均正相关(P<0.05)。结论:NVG组患者房水和血清中PlGF、IL-1β、TGF-β2水平显著高于对照组,可能与NVG疾病发生有关。

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	刘雪莲
	吴桂花
	张燕

关键词 ：新生血管性青光眼, 房水, 血浆, 胎盘生长因子, 转化生长因子β2, 白细胞介素1β

Abstract：Objective: To detect the levels of placental growth factor (PlGF), interleukin-1β (IL-1β), and transforming growth factor (TGF-β2) in aqueous humor and plasma of patients with neovascular glaucoma (NVG), and to explore the relationships between the levels of PlGF, IL-1β and TGF-β2 in aqueous humor and plasma. Methods:42 patients (42 eyes) diagnosed as NVG in our hospital from April 2016 to September 2018 were selected, 50 cases (50 eyes) of patients with age-related cataract (ARC) were selected as control group, enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of PlGF, IL-1β and TGF-β2 in aqueous humor and serum. Results: The levels of PlGF, IL-1β and TGF-β2 in aqueous humor and serum of patients in group NVG were significantly higher than those of ARC patients (P < 0.05); the levels of PlGF and TGF-β2 in aqueous humor were significantly higher than those in serum in group NVG (P < 0.05); there was no significant change in the levels of PlGF and TGF-β2 between aqueous humor with serum of ARC patients (P>0.05); the level of IL-1β in the two groups was significantly higher than that in the serum (P<0.05). Pearson test showed that the levels of PlGF, IL-1β and TGF-β2 in aqueous humor and serum of NVG patients were positively correlated (P < 0.05). Conclusion: The levels of PlGF, IL-1β and TGF-β2 in aqueous humor and serum of patients in group NVG are significantly higher than those in control group, it may be related to NVG disease.

Key words： Neovascular glaucoma Aqueous humor Plasma Placental growth factor Transforming growth factor β2 Interleukin 1β

基金资助:重庆市卫生计生委科研基金项目,(编号:2017MSXM179)

引用本文:

刘雪莲, 吴桂花, 张燕. 新生血管性青光眼患者房水和血浆中PlGF IL-1β和TGF-β₂的测定及意义[J]. 河北医学, 2019, 25(9): 1512-1515.
LIU Xuelian, WU Guihua, ZHANG Yan. Determinations and Significances of PlGF, IL-1β and TGF-β2 in Aqueous Humor and Plasma of Patients with Neovascular Glaucoma. HeBei Med, 2019, 25(9): 1512-1515.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2019.09.027 或 http://www.hbyxzzs.cn/CN/Y2019/V25/I9/1512

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