Abstract：Objective: To study the curative efficacy of tacrolimus combined with irbesartan in treatment of diabetic nephropathy and effects on serum angiopoietin-like protein 4 (Angptl4), growth differentiation factor-15(GDF-15) and connective tissue growth factor(CTGF) levels. Methods: 105 patients of diabetic nephropathy who received therapy from August 2016 to August 2018 in our hospital were selected as research objects, according to the random number table,those patients were divided into the 55 cases of the observation group and the 50 cases of the control group, they were received routine treatment, the control group was treated with irbesartan on the basis of the above, while the observation group was treated with tacrolimus injection on the basis of the control group, they were treated for 21 days. The changes of serum Angptl4, GDF-15, CTGF (Enzyme-linked immunosorbent assay), blood sugar, renal function and adverse reactions were observed in both groups. Results: After treatment, the serum Angptl4, GDF-15 and CTGF levels in the observation group were significantly lower than those in the control group (P＜0.05); there was no significant difference in fasting blood glucose (FBG), postprandial blood glucose (2hPG) and glycosylated hemoglobin (HbA1c) between the two groups before and after treatment (P＞0.05); the urea nitrogen (BUN), serum creatinine (SCr) and 24-hour urinary microprotein excretion rate (UAER) in the observation group were significantly lower than those in the control group (P＜0.05); there was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion: Tacrolimus combined with irbesartan is well for diabetic nephropathy, which can effectively reduce the expression of serum Angptl4, GDF-15 and CTGF, improve renal vascular function and promote the recovery of renal function, and without increasing adverse drug reactions, it has high clinical value.
颜文盛, 张艳飞, 龚锦强. 他克莫司联合厄贝沙坦治疗糖尿病肾病的疗效及对血清Angptl4 GDF-15 CTGF水平的影响[J]. 河北医学, 2019, 25(9): 1438-1442.
YAN Wensheng, ZHANG Yanfei, GONG Jinqiang. Curative Efficacy of Tacrolimus combined with Irbesartan in Treatment of Diabetic Nephropathy and Effects on Serum Angptl4 GDF-15 and CTGF Levels. HeBei Med, 2019, 25(9): 1438-1442.
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2019, Vol. 25 
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