Curative Effect of Rabeprazole Combined with Droperitiazole Meretroxine in the Treatment of Patients with Chronic Atrophic Gastritis and its Effect on Serum sIL-2R MDA and G-17
Abstract：Objective: To observe the curative effect of rabeprazole combined with droperitiazole meretroxine in the treatment of patients with chronic atrophic gastritis and its effect on serum soluble interleukin-2 receptor (sIL -2R), malondialdehyde (MDA) and gastric secrete element-17 (G-17). Methods: 96 cases of chronic atrophic gastritis patients from December 2015 to December 2017, according to the simple random number table method these patients were divided into control group and research group,48 cases in each group. control group was treated with rabeprazole, and the research group was treated with flupipertiazol tablet united rabeprazole. Then curative effect, SF-36 scale score, anxiety, depression scores and symptom scores,sIL-2R,MDA,G-17, and adverse reactions occur between two group were and compared. Results: Total effective rate of the experimental group 95.83% was significantly higher than the control group 79.18% (P<0.05). Before treatment, SF-36 scale score, anxiety, depression scores and symptom scores,sIL-2R,MDA,G-17 of two group was no statistically significant (P>0.05). 2 weeks after treatment, 4 weeks after treatment, SF-36 scale score, G-17 of experimental group was significantly increased than after the treatment, the treatment group was significantly higher than the control group, anxiety depression scale and symptom scores, sIL-2R, MDA of two group was significantly reduced than after treatment, the experimental group was significantly lower than the control group,the difference was statistically significant (P<0.05). The adverse effects rate in both group was no statistical significance (P>0.05). Conclusion: curative effect of rabeprazole combined with droperitiazole meretroxine in the treatment of patients with chronic atrophic gastritis is sure, can significantly improve the clinical symptoms of patients,improve health,,it may be more conducive to regulating sIL-2R, MDA, and G-17 levels.
王剑, 陈志涛, 周婷婷, 廖宇圣. 雷贝拉唑联合氟哌噻吨美利曲辛片治疗慢性萎缩性胃炎患者的疗效及对血清sIL-2R MDA G-17的影响[J]. 河北医学, 2019, 25(8): 1333-1335.
WANG Jian, CHEN Zhitao, ZHOU Tingting, et al. Curative Effect of Rabeprazole Combined with Droperitiazole Meretroxine in the Treatment of Patients with Chronic Atrophic Gastritis and its Effect on Serum sIL-2R MDA and G-17. HeBei Med, 2019, 25(8): 1333-1335.
2019, Vol. 25 
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