Abstract：Objective: To investigate the relationship between the serum levels of IL-23 and IL-35 and the stability of carotid atherosclerotic plaques in patients with acute cerebral infarction. Methods: 124 patients with acute cerebral infarction were divided into unstable plaque group, stable plaque group and non-plaque group according to the results of carotid ultrasonography, and 63 healthy people were selected as control group. Serum levels of IL-23 and IL-35 were compared in each group. Results: The level of serum IL-35 (18.8±6.7) ng/ml in the acute cerebral infarction group was significantly higher than that in the control group (8.7±4.1) ng/ml (P<0.01); the level of serum IL-23 (24.3±4.8) ng/ml in the acute cerebral infarction group was significantly higher than that in the control group (8.4+1.6) ng/ml (P<0.01). Academic significance (P<0.01). Serum IL-35 level (22.3±5.8) ng/ml in patients with unstable plaque was significantly higher than that in patients with stable plaque (15.3±1.6) ng/ml in patients with unstable plaque (P<0.01); serum IL-35 level (22.3±5.8) ng/ml and (15.3+1.6) ng/ml in patients with unstable plaque and patients with stable plaque were significantly higher than those in patients without plaque (10.7±4.1) ng/ml in patients with unstable plaque (P<0.01). The serum IL-23 level (36.9+6.4) ng/ml in unstable plaque group was significantly higher than that in stable plaque group (23.4±4.7) ng/ml (P<0.01); the serum IL-23 level (36.9±6.4) ng/ml and (23.4±4.7) ng/ml in unstable plaque group and stable plaque group were significantly higher than those in non-plaque group (11.4±1.6 ) ng/ml, the difference was statistically significant (P<0.01). Conclusion: The serum levels of IL-23 and IL-35 in patients with acute cerebral infarction may be related to the stability of carotid atherosclerotic plaque.
[1] M.Saini,M.S.Suministrado,S.Hilal,et al.Prevalence and risk factors of acute incidental infarcts[J]Stroke,2015,46(10),2722~2727. [2] L.Ye,R.Cai,M.Yang,et al.Hong reduction of the systemic inflammatory induced by acute cerebral infarction through ultra-early thrombolytic therapy[J] Exp Ther Med,2015,10(4),1493~1498 [3] T.Nakashima,T.Noguchi,S.Haruta,et al.Prognostic impact of spontaneous coronary artery dissection in young female patients with acute myocardial infarction: a report from the angina pectoris-myocardial infarction multicenter investigators in Japan[J].Int Cardiol,2016,207(5), 341~348. [4] 王志贵,范艺花.血清IL-23联合血浆脑钠肽检测对判断慢性心力衰竭患者预后的影响[J].河北医学,2014,(10):1601~1604. [5] Y. Zheng D,Zhong H,Chen S,et al.Pivotal role of cerebral interleukin-23 during immunologic injury in delayed cerebral ischemia in mice[J]. Neuroscience,2015,290(2):321~331. [6] 李舟文.急性脑梗死患者血清IL-23/IL-17水平与颈动脉粥样硬化斑块性质的相关性研究[J].中风与神经疾病杂志,2017,(7):618~620. [7] Lin-Chong Su,Xiao-Yan Liu,An-Fang Huang,et al. Emerging role of IL-35 in inflammatory autoimmune diseases[J]. Autoimmunity Reviews,2018,17(7):665~673.
2019, Vol. 25 
冀公网安备13080202000677号