Abstract：Objective: To explore the therapeutic effect of adrenal cortex hormones combined with cefuroxime in children with severe pneumonia and its effects on immune function. Methods: 180 cases of children with severe pneumonia admitted to our hospital from January 2015 to December 2017 were divided into the observation group (n=90) and the control group (n=90) according to the simple random grouping method. The two groups were given the removing phlegm, relieving asthma and cough and other conventional symptomatic treatment, and the control group was given the daily intravenous drop of cefuroxime, and the observation group was additionally given the intravenous drop of methylprednisolone. The clinical efficacy, the inflammatory factors levels [interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor α (TNF-α), C-reactive protein (CRP)] and immune function indexes were compared between the two groups. And the improvement time of antipyretic and pulmonary rales disappearance symptoms, and the ICU stay, total hospital stay and adverse reactions during treatment were recorded in the two groups. Results: The total effective rate of efficacy in the observation group was significantly higher than that in the control group [88.89% (80/90) vs 77.78% (70/90)] (P<0.05). After treatment, the levels of IL-10, CD3+, CD4+ and CD4+/ CD8+ in the observation group were significantly higher than those in the control group, and the levels of IL-6, TNF-α, CRP and CD8+ were significantly lower than those in the control group, and the antipyretic time and the pulmonary rales disappearance time were significantly earlier than those in the control group, and the ICU stay and total hospital stay were significantly shorter than those in the control group (P<0.05). The incidence rate of adverse reactions in the observation group was slightly lower than that in the control group [5.56% (5/90) vs 12.22% (11/90) ](P>0.05). Conclusion: Adrenal cortex hormones combined with cefuroxime can have an exact clinical efficacy in children with severe pneumonia, and it can significantly improve the inflammatory reactions and clinical symptoms, enhance the immune function and shorten the hospital stay, and it has high safety.
刘运军, 刘士虎. 肾上腺皮质激素联合头孢呋辛治疗重症肺炎患儿的效果及对免疫功能的影响[J]. 河北医学, 2019, 25(8): 1269-1272.
LIU Yunjun, LIU Shihu. Effect of Adrenocortical Hormone combined with Cefuroxime on Children with Severe Pneumonia and its Influence on Immune Function. HeBei Med, 2019, 25(8): 1269-1272.
2019, Vol. 25 
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