Abstract：Objective: To investigate the effect of transrectal Ultrasound Elastography (TRE) combined with prostate biopsy on the detection rate of prostate cancer (PCa), and to provide reference for clinical optimal diagnosis. Methods: 110 patients with suspected prostate cancer were examined by transrectal Ultrasound (TRUS) and TRE respectively, and puncture biopsy guided by TRUS was performed to compare the diagnostic effect of the two methods on PCa. Result: 53 cases Of 110 suspected PCa patients were diagnosed pathologically, accounting for 48.18% (53/110), 49 were benign prostatic hyperplasia (BPH), accounting for 44.55% (49/110), and 8 were chronic prostatitis (CP), accounting for 7.27% (8/110). The sensitivity, specificity and accuracy of TRUS-guided puncture biopsy in the diagnosis of PCa were 75.47% (40/53), 68.42% (39/57), 71.82% (79/110), and the positive and negative predictive values were 68.97% (40/58) and 75.00% (39/52), respectively, which were significantly lower than those of TRE-guided puncture biopsy in the diagnosis of PCa 92.45% (49/53), 94.74% (54/57), 93.64% (103/110), 94.23% (49/52), 93.10% (54/58), the difference was statistically significant (X2= 5.675, 13.134, 18.323, 11.331, 6.877, P<0.05 or <0.001), the number of needles under TRUS guidance was 815, the positive rate of puncture point was 18.77%(153/815), significantly lower than that under TRE guidance, the positive rate of target puncture point was 51.33% (116/226), the difference was statistically significant (X2 = 150.418, P<0.001). Conclusion: TRE-guided prostate biopsy can achieve the target biopsy of the lesion, improve the detection rate of PCa and positive rate of puncture point. It can be used as an effective means of early screening and diagnosis of PCa, and is worthy of clinical application.
2019, Vol. 25 
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