Abstract：Objective: To investigate the correlation between amnestic-type mild cognitive impairment(aMCI) and the changes in ROI of medial temporal lobe by voxel-based morphological (VBM-DARTEL) and Freesurfer. Methods: 3D-T1WI image data of aMCI group, AD group and NC group were collected. Gray matter density of hippocampus, amygdala, endoolfactory cortex and papillary body was measured quantitatively by VBM-DARTEL algorithm. The volume of hippocampus and amygdala subarea was segmented and calculated by Freesurfer software. ANOVA test and multiple comparisons were made among the three groups. Results: The gray values of ROI were different in AD-MCI-NC, AD-MCI and AD-NC groups except for the nipple in vitro. There was no difference among the four ROI groups in MCI-NC. There was no significant difference in AD, MCI, NC and multiple comparisons between the anterior and inferior hippocampal brackets. The left amygdala basal nucleus, lateral nucleus, cortical amygdala transitional area, paraaminic nucleus and bilateral hippocampal amygdala transitional area were only significant differences in differentiating early AD from normal adults. Conclusion: VBM and Freesurfer can objectively and accurately reflect the slight changes of the medial temporal lobe of amnestic mild cognitive impairment and early AD, and can significantly distinguish amnestic mild cognitive impairment from early AD and early AD from normal adults, but have low sensitivity to distinguish amnestic mild cognitive impairment from normal adults.
贺盼, 马强. 基于VBM-DARTEL与FreeSurfer内侧颞叶改变与遗忘型轻度认知障碍的相关性研究[J]. 河北医学, 2019, 25(7): 1062-1068.
HE Pan, MA Qiang. Study on the Relationship between Medial Temporal Lobe Changes and Amnestic Mild Cognitive Impairment Based on VBM-DARTEL and FreeSurfer. HeBei Med, 2019, 25(7): 1062-1068.
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2019, Vol. 25 
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