Abstract：Objective: To explore the preventive effect of Xuebijing injection on sepsis in severely burned patients and its effect on inflammatory factors. Methods: A total of 84 patients with severe burns admitted to our hospital from July 2015 to December 2017 were divided into observation group and control group by simple random grouping, with 42 cases in each group. After admission, both groups were treated with conventional burns, including: nutritional support, organ protection, fluid resuscitation, antibiotics, and conventional wound debridement and dressing change. On the basis of this, the observation group applied Xuebijing injection: 50 ml/time, twice/d for 1 week. The incidence of sepsis, serum levels of creatinine (Cr), urea nitrogen (BUN), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), acute physiology and chronic health (APACHE) score, sequential organ failure score (SOFA) at the time of admission and 1 week of treatmentwere compared between the two groups. Results: The incidence of sepsis in the observation group was 11.90% (5/42), and 30.95% (13/42) in the control group, the difference was statistically significant (P<0.05). There were no significant differences in serum levels of TNF-α, IL-6, Cr, BUN, APACHE scores, and SOFA scores between the two groups (P>0.05). After 1 week of treatment, the serum levels of TNF-α, IL-6, Cr, BUN, APACHE and SOFA were significantly lower than those at admission in both group (P<0.05). The serumlevels of TNF-α, IL-6, Cr, BUN, APACHEscore and SOFA scoreat 1 week of treatmentin the observation group were significantly lower than those in the control group(P<0.05). Conclusion: On the basis of routine treatment of western medicine, Xuebijing injection can treat severe burns, which can effectively improve the overall physiological condition of patients, inhibit inflammatory factors, block inflammatory damage induced by inflammatory transmitters, protect kidney function and prevent the occurrence of sepsis, the effect is significant, it is worth promoting.
孙同祖. 血必净注射液对重度烧伤患者发生脓毒症的预防作用及对炎性因子的影响[J]. 河北医学, 2019, 25(6): 969-971.
SUN Tongzu. Preventive Effect of Xuebijing Injection on Sepsis in Patients with Severe Burn and Its Effect on Inflammatory Factors. HeBei Med, 2019, 25(6): 969-971.
[1] 贾凤玉,任红旗,龚德华,等.连续性血液净化治疗在重度烧伤患者救治中的应用[J].肾脏病与透析肾移植杂志,2016,25(1):30~34. [2] Bonde A, Nordestgaard AT, Kirial R, et al. The effect of resuscitation strategy on the longitudinal immuno-inflammatory response to blunt trauma[J].Injury,2017,48(12):2670~2674. [3] 韩永强,史辉,关炳星,等.血必净对贲门癌术后胸腔感染发生脓毒症的防治效果及对血小板参数的影响[J].血栓与止血学,2017,23(2):316~318. [4] 师灵灵,韩艳秋,任慧娟,等.脓毒症的病理生理机制研究进展[J].中华医院感染学杂志,2016,26(8):1914~1916. [5] 高戈,冯喆,常志刚,等.2012国际严重脓毒症及脓毒性休克诊疗指南[J].中华危重病急救医学,2013,25(8):501~505. [6] Vardas K, Ilia S, Sertedaki A, et al. Increased glucocorticoid receptor expression in sepsis is related to heat shock proteins, cytokines, and cortisol and is associated with increased mortality[J].Intensive Care Med Exp,2017,5(1):10~13. [7] 王煜,刘伟,赵敏.血必净注射液对严重脓毒症患者免疫功能的影响[J].实用药物与临床,2014,17(1):53~56. [8] Yoon J, Kim Y, Yim H, et al. Analysis of prognostic factors for acute kidney injury with continuous renal replacement therapy in severely burned patients[J].Burns,2017,43(7):1418~1426. [9] 赵彩霞,靳会欣.丹参多酚酸盐的药理作用机制及临床应用研究进展[J].河北医药,2017,39(2):294~299. [10] 邵礼梅,许世伟,苏玉娟,等.红花药物分析、化学成分及现代药理研究进展[J].中医药信息,2017,34(2):123~125. [11] Schleder S, Luerken L, Dendl LM, et al. Impact of multidetector computed tomography on the diagnosis and treatment of patients with systemic inflammatory response syndrome or sepsis[J].Eur Radiol,2017,27(11):4544~4551.
2019, Vol. 25 
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