Abstract：Objectives: To investigate the correlation between serum levels of 25-hydroxyvitamin D (25OH-D) and dermatomyositis-associated pulmonary interstitial disease (DM-ILD). Methods: 81 cases of DM-ILD were selected from March 2016 to February 2017 in our hospital department of rheumatism in our hospital as the research object (research group), 82 DM patients and 80 healthy volunteers were selected as control group and healthy-control group in the same period. The serum levels of 25OH-D in each group were tested by the method of high performance liquid chromatography combined with tandem mass spectrometry.And the differences of 25OH-D levels among the groups were analyzed. Results: The serum levels of 25OH-D in research group was significantly lower than the control group and healthy-control group, and the difference were statistically significant (P<0.01). The serum level of 25OH-D in the control group was significantly lower than that in healthy control group, and the difference were statistically significant (P<0.05). The serum level of 25OH-D in research group was 97.53% which was significantly higher than that in the control group (43.90%)(P=0.035).The proportions of patients with ‘severely deficient’ or ‘lack’ of 25OH-D serum levels in research group were significantly higher than that in control group (P<0.05). Conclusions: The lower serum level of 25OH-D in patient with DM-ILD is closely related with DM-ILD, and it has a certain clinical value for the early diagnosis of DM-ILD.
[1] SunY, He Y, Liu Y,et al. Biologics in polymyositis anddermatomysitis-associated interstitial lung disease [J]. Curr Pharm Biotechnol, 2014, 15(6): 521~524. [2] Troyoanov Y, Targoff IN, Payette MP, et al.Redefining dermatomyositis:a description of new diagnostic criteria that differentiate pure dermatomyositis from overlap myositis with dermatomyositis features [J]. Medicine,2014,93(24):318~332. [3] Hallowell RW, Ascherman DP, Danoff SK, et al. Pulmonary manifestations of polymyositis / dermatomyositis [J]. Semin Respor Crit Med, 2014, 35(2): 239~248. [4] 张丽华,庞丽霞,林涛,等.某院风湿免疫科成年患者25-羟维生素D水平现况调查[J].药物流行病学杂志,2016,25(5):326~328. [5] Shi Y, Liu T, Yao L, et al. Chronic vitamin D deficiency induces lung fibrosis through activation of the renin-angiotensin system [J].Sci Rep, 2017, 7(1): 3312~3313. [6] Auriemma M,Capo A,Meogmssi G,et a1.Cutaneous signs of classical dematomyositis[J]. G Ital Dermatol Venereol,2014,149(5):505~517. [7] Khayznikov M,KUMAR A,WANG P,et al.Statin intolerance and vitamin D supplementation[J].N Am Med Sci,2015,7(7):339~340. [8] 梁志强,姜凤云,赵蕾,等.肺泡呼出气一氧化氮联合25羟维生素D测定对系统性硬化症相关肺间质病变的临床价值[J].解放军医学院学报,2017,38(11):1~2.
2019, Vol. 25 
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