Abstract：Objective: To investigate the effect of cetuximab combined with different chemotherapy regimens in patients with advanced rectal cancer. Methods: 60 patients with advanced rectal cancer in our hospital were enrolled according to the random number table. 30 patients in FOLFIRI group received cetuximab plus FOLFIRI chemotherapy, and 30 patients in FOLFOX4 group received cetuximab plus FOLFOX4 chemotherapy Treatment. Observe and compare clinical treatment effects and serum epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1) levels, T lymphocyte subsets (CD3+) (CD4+) level changes before and after treatment, and statistical changes in the quality of life (independence, physiological function, psychological function, social relationship) scores before and after treatment, and the incidence and survival of adverse reactions. Results: The disease control rate was 66.67% (20/30) in FOLFOX4 group and 56.67% (17/30) in FOLFIRI group. There was no significant difference between the two groups (P > 0.05). The level of serum EGFR in two groups was significantly lower than that before treatment (P < 0.05), but there was no significant difference between the two groups (P > 0.05). The levels of serum VEGF and IGF-1 in FOLFOX4 group were lower than those in FOLFIRI group after 2 cycles of treatment (P < 0.05); there was no significant difference in the incidence of liver dysfunction between the two groups (P > 0.05); the incidence of leukopenia in FOLFOX4 group was 3.33% (1/30), and the incidence of nausea and vomiting was 3.33% (1/30). The incidence of diarrhea was 10.00% (3/30), the incidence of thrombocytopenia was 6.67% (2/30), which was lower than that of FOLFIRI group (P < 0.05); the median progression-free survival time of FOLFOX4 group was 11.2 months, and the median overall survival time was 28.90 months, which was higher than that of FOLFIRI group (7.03 months, 19.90 months) (P < 0.05). Conclusion: Cetuximab combined with oxaliplatin-based FOLFOX4 chemotherapy regimen for advanced rectal cancer patients is effective and safe. It can reduce serum levels of vascular endothelial growth factor and insulin-like growth factor-1 and prolong the survival time of patients.
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2019, Vol. 25 
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