Abstract：Objective: To investigate the clinical value of serum neuron specific enolase (NSE) and γ-glutamyltranspeptidase (γ-GT) in the diagnosis of neonatal bilirubin encephalopathy (NBE). Methods: A total of 340 children with neonatal hyperbilirubinemia admitted to our hospital from March 2014 to September 2018 were enrolled. Among them, 108 patients with NBE were in the study group and 232 patients with non-NBE were in the control group. The serum levels of total bilirubin (TBIL), indirect bilirubin (IBIL), NSE, and γ-GT were observed. To analyze the correlation between TBIL, IBIL and NSE, γ-GT; to evaluate the value of NSE, γ-GT and their combined diagnosis of NBE. Results: The serum levels of TBIL, IBIL, NSE and γ-GT in the study group were higher than those in the control group, and the difference was statistically significant (P<0.05). Correlation analysis showed that TBIL and IBIL were positively correlated with NSE and γ-GT levels (P<0.05); NSE was also positively correlated with γ-GT (P<0.05). ROC curve analysis showed that the area under the curve (AUC) of serum NSE, γ-GT and the combined diagnosis of the two were 0.876, 0.825, 0.890; The sensitivity and specificity corresponding to the optimal threshold point were: NSE 72.2%, 93.1%, γ-GT 72.2%, 85.3%, and the combined diagnosis was 82.4% and 84.9%; The combined diagnostic efficacy of the two is higher than the single diagnosis. Conclusion: Serum NSE and γ-GT have diagnostic value for NBE, and NSE is superior to γ-GT, and the combination of the two has the highest diagnostic efficiency, which can provide an objective reference for early auxiliary evaluation of NBE.
袁玲, 王军. 神经元特异性烯醇化酶及血清γ-GT在诊断新生儿胆红素脑病中的价值[J]. 河北医学, 2019, 25(6): 931-934.
YUAN Ling, WANG Jun. The Value of Neuron Specific Enolase and Serum γ-GT in the Diagnosis of Neonatal Bilirubin Encephalopathy. HeBei Med, 2019, 25(6): 931-934.
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2019, Vol. 25 
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