2025年4月8日 星期二
首页        期刊介绍        编委会        投稿指南        期刊订阅        广告合作        联系我们        English
河北医学  2019, Vol. 25 Issue (6): 1027-1029    DOI: 10.3969/j.issn.1006-6233.2019.06.039
  临床研究 本期目录 | 过刊浏览 | 高级检索 |
外周血Th22细胞在类风湿性关节炎中的作用及临床意义
唐艳1, 朱良琼2, 周丽1, 徐春美1
1.陆军军医大学(第三军医大学大坪医院(野战外科研究所), 重庆 400042;
2.重庆市中医院手术室, 重庆 400011
The Role and Clinical Value of Th22 Cells in Peripheral in Rheumatoid Arthritis
TANG Yan, et al
Daping Hospital & Institute of Surgery Research, Army Medical University / The Third Military Medical University, Chongqing 400042, China
全文: PDF (1486 KB)   HTML (1 KB) 
输出: BibTeX | EndNote (RIS)      
摘要 目的: 探讨外周血Th22细胞在类风湿性关节炎(RA)中的作用及临床意义。方法: 以190例RA患者为研究对象,根据DAS28评分,将RA患者按病情活动程度分为DAS28≤3.2两组(52例)、3.2<DAS28≤5.1组(63例)、DAS28>5.1组(75例),同时选取60例健康体检人群为对照组。采用流式细胞仪检测各组外周血Th22细胞水平;酶联免疫吸附法检测相关细胞因子(IL-22、IL-17)水平,分别比较各组外周血Th22细胞水平的差异,评价外周血Th22细胞水平对RA患者病情活动程度的预测价值。结果: 与健康对照组比较,RA组患者外周血Th22细胞及细胞因子IL-22水平显著升高(P<0.05);不同活动程度RA组间外周血Th22细胞、IL-22及IL-17水平比较,差异具有统计学意义(P<0.05)。其中,DAS28>5.1组上述指标水平最高,3.2<DAS28≤5.1组次之,DAS28≤3.2两组最低,(P<0.05)。RA组患者外周血Th22细胞水平与IL-22、IL-17及DAS28评分呈显著正相关(r=0.831,P=0.000;r=0.575,P=0.025;r=0.673,P=0.014)。ROC曲线分析显示,外周血Th22细胞水平曲线下面积为0.874(95%CI 0.801~0.948),其最佳工作点为8.5%,此时预测RA患者病情活动程度的敏感性和特异性分别为84.38%和81.48%。结论: 外周血Th22细胞水平与RA患者的发生、发展密切相关,对于RA患者病情活动程度的预测,具有一定的应用价值。
服务
把本文推荐给朋友
加入我的书架
加入引用管理器
E-mail Alert
RSS
作者相关文章
关键词 Th22细胞白介素-22白介素-17类风湿性关节炎    
AbstractObjective: To study the role and clinical value of Th22 cells levels in peripheral blood in rheumatoid arthritis (RA). Methods: According to the DAS28 score, 190 patients with RA were divided into DAS28≤3.2 (52 cases), 3.2<DAS28≤5.1 (63 cases), DAS28>5.1 (75 cases), 60 healthy subjects were selected as the control group. The levels of Th22 cells in peripheral blood of each group were detected by flow cytometry. The levels of related cytokines (IL-22, IL-17) were detected by enzyme-linked immunosorbent assay (ELISA). The differences of Th22 cells in peripheral blood were compared. The predictive value of Th22 cell in peripheral blood was evaluated in the degree of activity in RA. Results: Compared with healthy controls, the levels of Th22 cells and cytokine IL-22 in peripheral blood in patients with RA were significantly increased (P<0.05); The levels of Th22 cells, IL-22 and IL-17 in peripheral blood in different activity degrees of RA were statistically signifiant (P<0.05). Among them, the level of the above indicators in the DAS28>5.1 group was the highest, the 3.2<DAS28≤5.1 group was the second, and the DAS28≤3.2 group was the lowest. The level of Th22 cells in peripheral blood in patients with RA group was positively correlated with IL-22, IL-17 and DAS28 (r=0.831, P=0.000; r=0.575, P=0.025; r=0.673, P=0.014). ROC curves analysis showed that the area under curve of Th22 cells was 0.874 (95%CI 0.801~0.948), and optimal operating point (OOP) was 8.5%, which had 84.38% sensiticity and 81.48% specificity in predicting the activity degree of RA patients. Conclusions: The level of Th22 cells in peripheral blood is closely related to the occurrence of development of RA patients, and there is certain application value for predicting the activity degree of RA.
Key wordsTh22 cell    Interleukin-22    Interleukin-17    Rheumatoid arthritis
    
基金资助:国家自然科学基金项目,(编号:81300197)
通讯作者: 徐春美   
引用本文:   
唐艳, 朱良琼, 周丽, 徐春美. 外周血Th22细胞在类风湿性关节炎中的作用及临床意义[J]. 河北医学, 2019, 25(6): 1027-1029.
TANG Yan, et al. The Role and Clinical Value of Th22 Cells in Peripheral in Rheumatoid Arthritis. HeBei Med, 2019, 25(6): 1027-1029.
链接本文:  
http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2019.06.039     或     http://www.hbyxzzs.cn/CN/Y2019/V25/I6/1027
冀ICP备2025106803号    冀公网安备13080202000786号
版权所有 © 2016 《河北医学》杂志社
本系统由北京玛格泰克科技发展有限公司设计开发