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河北医学  2019, Vol. 25 Issue (6): 1017-1019    DOI: 10.3969/j.issn.1006-6233.2019.06.036
  临床研究 本期目录 | 过刊浏览 | 高级检索 |
维持性血液透析患者并发心脑血管病的危险因素及对患者近期预后的影响
薛亚辉, 王怡
北京市第六医院, 北京 100007
Risk Factors of Cardio-cerebrovascular Disease in MaintenanceHemodialysis Patients and its Impact on Short-term Prognosis
XUE Yahui, WANG Yi
Beijing Sixth Hospital, Beijing 100007, China
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摘要 目的: 探讨维持性血液透析(MHD)患者并发心脑血管病的危险因素及对患者近期预后的影响。方法: 选取我院2013年3月至2018年6月行MHD的患者98例作为研究对象,根据是否并发心脑血管疾病划分为并发组和非并发组,对患者的临床信息进行分析,寻找患者并发心脑血管病的危险因素。对患者进行2年的随访,记录患者生存、转归情况。结果: 纳入并发组的有35例,MHD患者心脑血管疾病发生率为35.71%;单因素分析结果显示:高血压病史(χ2=10.671,P=0001)、透析龄(t=4.519,P<0.001)、UA水平(t=21.992,P<0.001)为MHD患者心脑血管疾病的相关因素,而与性别、糖尿病病史、血清白蛋白、Scr、BUN、TG、TC、LDL-C、HDL-C、Hb水平无关,差异无统计学意义(P>0.05);二元Logistic回归分析结果显示,有高血压病史、透析龄长、UA水平高是MHD患者心脑血管疾病发生的危险因素(P均<0.05);随访发现并发组患者2年生存率明显低于非并发组,比较差异具有统计学意义(P<0.05)。结论: MHD患者并发心脑血管疾病预后较差,有高血压病史、透析龄长、UA水平高是MHD患者心脑血管疾病发生的危险因素,临床需引起重视。
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薛亚辉
王怡
关键词 维持性血液透析心脑血管病预后危险因素血尿酸    
AbstractObjective: To explore the risk factors of cardiovascular and cerebrovascular diseases in patients with maintenance hemodialysis (MHD) and its influence on short-term prognosis. Methods: 98 patients with MHD in our hospital from March 2013 to June 2018 were selected as the study subjects. According to whether they were complicated with cardiovascular and cerebrovascular diseases, they were divided into concurrent group and non-concurrent group. The clinical information of patients was analyzed to find out the risk factors of cardiovascular and cerebrovascular diseases. The patients were followed up for 2 years, and their survival and prognosis were recorded. Results: 35 cases were included in the concurrent group, and the incidence of cardiovascular and cerebrovascular diseases was 35.71% in MHD patients. Univariate analysis showed that hypertension (χ2= 10.671, P = 0001), dialysis age (t = 4.519, P<0.001), UA level (t=21.992, P<0.001) were related factors of cardiovascular and cerebrovascular diseases in MHD patients, but not with sex, diabetes history, serum albumin, Scr, BUN, TG, TC, LDL-C, HDL-C and Hb levels. The difference was not statistically significant(P>0.05).The results of binary logistic regression analysis showed that hypertension history, long dialysis age and high UA level were risk factors for cardiovascular and cerebrovascular diseases in MHD patients(P<0.05).The 2-year survival rate of the concurrent group was significantly lower than that of the non-concurrent group (P<0.05). Conclusion: The prognosis of MHD patients complicated with cardiovascular and cerebrovascular diseases is poor. Hypertension history, long dialysis age and high UA level are risk factors for the occurrence of cardiovascular and cerebrovascular diseases in MHD patients.
Key wordsMaintenance hemodialysis    Cardio cerebrovascular disease    Prognosis    Risk factors    Blood uric acid
    
基金资助:北京自然科学基金项目,(编号:7122153)
引用本文:   
薛亚辉, 王怡. 维持性血液透析患者并发心脑血管病的危险因素及对患者近期预后的影响[J]. 河北医学, 2019, 25(6): 1017-1019.
XUE Yahui, WANG Yi. Risk Factors of Cardio-cerebrovascular Disease in MaintenanceHemodialysis Patients and its Impact on Short-term Prognosis. HeBei Med, 2019, 25(6): 1017-1019.
链接本文:  
http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2019.06.036     或     http://www.hbyxzzs.cn/CN/Y2019/V25/I6/1017
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