Abstract：Objective: To study the effects of nicergoline combined with vinpocetine on hemorheology and inflammatory response in patients with cerebral infarction. Methods: 116 cases of patients with cerebral infarction in our hospital were selected and randomly divided into control group and observation group, with 58 cases in each group. Both groups were treated with routine therapy, while the control group was treated with vinpocetine; the observation group was treated with nicergoline tablets on the basis of the control group. The observation group was treated with nicergoline tablets on the basis of the control group, and the curative effect was evaluated after 2 weeks of treatment. The hemorheological parameters, inflammatory reaction factors and functional scale scores of the two groups were observed before and after treatment, and adverse drug reactions during treatment were recorded. Results: After treatment, the whole blood ratio, high shear viscosity, low shear viscosity and plasma specific viscosity in the observation group were lower than those in the control group (P<0.05). The levels of TNF-a, IL-6 and hs-CRP in the observation group were significantly lower than those in the control group (P<0.05). The NIHSS and improved Barthel index scores of the observation group were significantly improved compared with those of the control group (P<0.05). And the incidence of adverse drug reactions was similar between the two groups during the treatment period (P>0.05). Conclusions: Nicergoline combined with vinpocetine for patients with cerebral infarction can significantly reduce the hemorheology parameters and serum inflammatory factors levels, improve the patients' coagulation function, and does not increase adverse drug reactions.
2019, Vol. 25 
冀公网安备13080202000677号