Observation of Carative Effect of Intravitreal Injection of Ranibizumab Combined with 532nm Laser Photocoagulation in Patients with Ischemic Retinal Vein Occlusion
LU Jun, QIN Yu, XIAO Wenwei, et al
Shanghai Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China
Abstract：Objective: To observe the short-term efficacy of intravitreal injection of ranibizumab combined with 532nm laser photocoagulation in patients with ischemic retinal vein occlusion (RVO). Methods: From October 2015 to October 2017, 78 patients (78 eyes) with ischemic RVO were enrolled. According to the random number table, 39 patients (39 eyes) and 39 patients (39 eyes) were included in the control group. The control group was treated with 532 nm laser photocoagulation. The experimental group was treated with intravitreal injection of ranibizumab plus 532 nm laser photocoagulation. Six-month follow-up after treatment was proceeded; the clinical effects, quality of life score (SF-36) retinal leakage and best corrected visual acuity (BCVA), macular central retinal thickness (CMT) during pre-treatment, 1 month, 3 months, 6 months after treatment were compared. Results: The total effective rate of the test group was 94.87% higher than that of the control group at 6 months after treatment, and the difference was statistically significant (P<0.05). The degree of retinal leakage in the test group was lower than that of the control group at 6 months after treatment. The difference was statistically significant. Significance (P<0.05); BCVA and SF-36 scores increased at 1 month, 3 months, and 6 months after treatment, and the test group increased significantly. The BCVA group and the different time points in the two groups. Compared with the interaction between groups and at different time points, the difference was statistically significant (P<0.05). The CMT of the two groups decreased at 1 month, 3 months and 6 months after treatment, and the test group decreased greatly. There was statistically significant difference between the two groups of CMT groups, at different time points, and between groups at different time points (P<0.05). Conclusion: Patients with ischemic retinal vein occlusion combined with intravitreal injection of ranibizumab and 532nm laser photocoagulation can improve clinical outcomes, improve visual acuity, reduce retinal leakage and macular edema, and improve patients' quality of life.
2019, Vol. 25 
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