Clinical Efficacy of Aspirin combined with Low Molecular Weight Heparin in the treatment of Fetal Growth Restriction and its Influence on Fetal Blood Flow Parameters and Maternal and Infant Outcomes
CHEN Yongli
Shiyan People's Hospital of Hubei / Hubei Medical College Affiliated People's Hospital, Hubei Shiyan 442000, China
Abstract：Objective: To investigate the clinical curative effect of aspirin combined with low molecular weight heparin (LMWH) in the treatment of fetal growth restriction (FGR) and the influence on fetal blood flow parameters and maternal and neonatal outcomes. Methods: 180 pregnant women with FGR caused by umbilical cord and placental abnormalities were divided into the study group (100 cases) and the control group (80 cases) according to different regimens. The situation of fetal development was determined after admission and confirmed diagnosis and was monitored. The control group was treated by subcutaneous injection of LMWH preparation Low Molecular Weight Heparin Calcium Injection. On the basis, the study group was treated with oral Aspirin Enteric-coated Tablets. According to the results of color Doppler ultrasonography, the curative effect was evaluated. The parameters of umbilical artery, such as fetal pulsatility index (PI), resistance index (RI), peak systolic blood flow velocity (S) and peak diastolic end blood flow velocity (D) were detected. Maternal and neonatal outcomes were statistically analyzed. Results: The total effective rate of treatment in the study group was significantly higher than that in the control group (79.00% vs 65.00%) (P<0.05). PI, RI and S/D of the two groups were close before treatment (P>0.05), but they were significantly decreased after treatment, and the decrease in study group was significantly greater than that in the control group (P<0.05). The incidence rates of placental abruption, fetal distress, neonatal asphyxia, premature infants and extremely low birth weight infants in the study group were slightly lower than those in the control group (P>0.05). Conclusion: Aspirin combined with LMWH can effectively improve the fetal blood flow parameters and improve the clinical curative effect on FGR to a certain extent. However, the improvement of curative effect and maternal and neonatal outcomes is limited.
陈永利. 阿斯匹林联合低分子肝素治疗胎儿生长受限的临床疗效及对胎儿血流参数变化母婴结局的影响[J]. 河北医学, 2019, 25(3): 691-694.
CHEN Yongli. Clinical Efficacy of Aspirin combined with Low Molecular Weight Heparin in the treatment of Fetal Growth Restriction and its Influence on Fetal Blood Flow Parameters and Maternal and Infant Outcomes. HeBei Med, 2019, 25(3): 691-694.
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2019, Vol. 25 
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