Abstract：Objective: To analyze the related factors of parenteral nutrition associated cholestasis in preterm infants. Methods: 150 premature infants treated with parenteral nutrition (PN) in our hospital from June 2016 to May 2018 were divided into two groups according to whether they belong to parenteral nutrition-related cholestasis (PNAC), non-PNAC group and PNAC group, including 100 non-PNAC premature infants and 50 PNAC premature infants. The clinical data of two groups of premature infants were compared. Logistic regression analysis was used to analyze the risk factors of PNAC in premature infants. Results: The gestational age and birth weight of children in non-PNAC group were (34.93±1.92) weeks and (1398.34±283.44) g, respectively, higher than those in PNAC group (30.02±1.23) weeks) and (1243.45±213.33) g (t=4.384, t=9.233, all P<0.05). The rates of anemia and neonatal infection in the PNAC group were 82.00% and 76.00%, respectively, which were significantly higher than those in the non-PNAC group 57.00% and 53.00% (χ2=7.384, χ2=7.555, P<0.05). The fat milk calorie ratio, amino acid caloric ratio, fasting time and feeding difficulty rate in non-PNAC group were significantly lower than those in PNAC group (t = 4.934, t = 5.874, χ2=7.384, P< 0. 05). The total calorie and milk caloric ratio in PNAC group were significantly lower than those in non-PNAC group (t = 6.372,t = 5.483, P< 0. 05). Neonatal infection, gestational age, fat milk caloric ratio, amino acid supply calorie ratio, fasting time and so on are all related to the occurrence of PNAC in preterm infants. The risk factors of PNAC (all P< 0. 05) and the ratio of calorie supply of milk were the protective factors of PNAC in preterm infants (P<0. 05). Conclusion: The related factors affecting the occurrence of parenteral nutrition-related cholestasis in preterm infants mainly include neonatal infection, low gestational age, high calorie supply ratio of amino acids and fat emulsion, and long fasting time. To formulate corresponding preventive measures can effectively reduce the incidence of PNAC in preterm infants.
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2019, Vol. 25 
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