Abstract：Objective: To analyze the pathogenic microorganism of infantile diarrhea pathogenic factors and the changes of serum interferon-γ(IFN-γ), interleukin-6 (IL-6), and transgenic growth factor -β(TGF-β). Methods: 100 cases of Infantile diarrhea children who treated from May 2015 to May 2018 in our hospital, according to the severity of the disease those children were divided into 41 cases of light group and 59 cases of heavy group, and 41 cases of healthy infants were selected for outpatient physical examination in the same period as a control group. The distribution of pathogenic microorganisms in infants and young children with diarrhea was analyzed, and the serum levels of IFN-γ, IL-6 and TGF-βin each group were compared, and the correlation was analyzed. Results: A total of 100 stool samples from infants with diarrhea were collected,a total of 80 pathogenic microorganisms were detected,the total detection rate was 83.00%, which the detection rate of rotavirus was 37.34%, the detection rate of calicivirus was 28.91%, the detection rate of small double-section virus was 9.63%, the detection rate of adenovirus was 8.43%, The detection rate of bacteria was 6.02%, and the detection rate of remaining viruses and bacteria was low. The serum levels of IFN-γ, IL-6 and TGF-β in the research group were lower than those in the control group, and the difference was statistically significant (P<0.05). The levels of serum IFN-γ, IL-6 and TGF-β in the severe group were higher than those in the light group (P<0.05).The areas of serum IFN-γ, IL-6, TGF-β and combined index ROC curves were 0.770, 0.788, 0.859, 0.940,the ROC curve area of the combined indicator was significantly higher than the individual indicators of IFN-γ, IL-6 and TGF-β. Conclusion: rotavirus is the main pathogenic microorganism of infantile diarrhea,analysis of serum IFN-γ, IL-6, TGF-β levels can be useful for the observation of disease diagnosis and progression.
潘淑, 张婧, 马瑜珊. 婴幼儿腹泻病原微生物检测及血清IFN-γ IL-6 TGF-β 的变化分析[J]. 河北医学, 2019, 25(3): 671-674.
PAN Shu, ZHANG Jing, MA Yushan. Detection of Pathogenic Microorganism of Infantile Siarrhea and Analysis of Changes of IFN-γ IL-6 and TGF-β. HeBei Med, 2019, 25(3): 671-674.
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2019, Vol. 25 
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