Changes of Serum PCT, Endothelin, eNOS and NFκB levels in Patients with Intracranial Infection after Craniocerebral Trauma and their Clinical Significance
YIN Jie, MOLADING·Abulizi, ZHENG Xi
The 474 Hospital of PLA, Xinjiang Urumqi 830001, China
Abstract：Objective: To investigate the changes of procalcitonin (PCT), endothelin (ET-1), endothelial nitric oxide synthase (eNOS) and nuclear factor (NFκB) levels in patients with intracranial infection after craniocerebral trauma and their clinical significance. Methods: 182 patients undergoing operation of traumatic brain injury and 30 healthy subjects were enrolled in the study. The patients were divided into infected group and uninfected group according to the criteria of intracranial infection. According to the anti-infective effect, patients in the infected group were divided into the controlled group and the uncontrolled group. Serum PCT, ET-1, eNOS and NFκB levels in each group were determined. The diagnostic efficiency of each index for infection was compared between groups. Results: Serum PCT, ET-1, eNOS and NFκB levels showed in the infected and uninfected groups were significantly higer than those in the control group (P<0.05). The levels of serum PCT, ET-1, eNOS and NFκB in the uncontrolled group were significantly higher than those in the controlled group (P<0.05). ROC curve analysis showed that the area under the curve of serum PCT was the largest and the diagnostic efficiency was the highest. With serum PCT =0.32μg/L as the best cut-off point, the diagnostic sensitivity and specificity were 88.6% and 91.6%, respectively. Conclusion: The levels of serum PCT can reflect the status of intracranial infection to a certain extent, and they can be used as reference indexes for the diagnosis of intracranial infection and evaluation of prognosis
2019, Vol. 25 
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