Abstract：Objective: To explore the value of multiple dispersion sensitivity coefficient (b-value) diffusion-weighted imaging (DWI) combined with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in the differential diagnosis of prostate cancer (PCa) and benign prostatic hyperplasia (BPH). Methods: The clinical data of 82 patients suspected as PCa (observation group) from January 2014 to March 2018 were retrospectively analyzed. Another 30 healthy examiners at the same time period were selected as control group. All patients and control group were given DWI and DCE-MRI. The DWI signal intensity value (SI) and apparent diffusion coefficient value (ADC) were evaluated at different b values, and the values of single DWI, single DCE-MRI and combined detection were compared in the differential diagnosis of prostate diseases. Results: The accuracy was the highest by DWI combined with DCE-MRI, and the accuracy was the lowest by DCE-MRI (P<0.05). The sensitivity was the highest by combined detection, and the sensitivity was the lowest by DCE-MRI (P>0.05). The specificity was the highest by combined detection, and was the lowest by DCE-MRI (P>0.05). There was no statistically significant difference in the specificity of PCa by multiple b-value DWI and DCE-MRI (P>0.05). The accuracy and sensitivity of PCa by multiple b-value DWI were higher than those by DCE-MRI (P>0.05). When b=800, 1000s/mm2, the SI of PCa was higher than that of BPH and normal prostate tissue while the ADC of PCa was lower than that of BPH and normal prostate tissue (P<0.05). There were no significant differences between BPH and normal prostate tissue in the SI and ADC (P>0.05). When b=800s/mm2, the PC and ADC of PCa, BPH and normal prostate tissue were higher than those when 1000s/mm2 (P<0.05). Conclusions: Multiple b-value DWI combined with DCE-MRI has good diagnostic efficiency in the differential diagnosis of PCa and BPH, and it is beneficial to improve the accuracy of clinical diagnosis.
李鹏, 梁浩然. 多弥散敏感系数DWI和DCE-MRI联合在前列腺癌及前列腺增生鉴别诊断的价值研究[J]. 河北医学, 2019, 25(2): 193-196.
LI Peng, et al. Value of Multiple b-value DWI combined with DCE-MRI in the Differential Diagnosis of Prostate Cancer and Benign Prostatic Hyperplasia. HeBei Med, 2019, 25(2): 193-196.
2019, Vol. 25 
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