Clinical Value of Detection of High-sensitivity C-reactive Protein and Cystatin C in Patients with Ventricular Remodeling after Acute Myocardial Infarction
LI Lin, LIU Jin, HUANG Chuang, et al
Guigang People's Hospital, Guangxi Guigang 537100, China
Abstract：Objective: To investigate the correlation between the levels of serum hypersensitive C-reactive protein (Hs-CRP) and cystatin C (CysC) and the degree of ventricular remodeling after acute myocardial infarction (AMI). Methods: 160 patients with AMI were selected as the observation group, and 80 patients with physical examination at the same time were selected as the control group. The serum levels of Hs-CRP and CysC were measured within 24 hours after the onset of the disease in the observation group and in the control group. According to the concentration levels of Hs-CRP and CysC, the observers were divided into four groups: group A had elevated serum Hs-CRP and CysC levels, group B had elevated serum Hs-CRP levels and CysC levels were normal, group C had elevated normal CysC levels of Hs-CRP, and group D had normal Hs-CRP and CysC levels. The follow-up period was 6 months. The left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular ejection fraction (LVEF) were measured by echocardiography within 96 hours after onset and at the end of follow-up (6 months) as well as in the control group. The left ventricular remodeling was defined as the growth rate of left ventricular end-diastolic volume (LVEDV%>20%) at the end of follow-up (6 months). The indexes of echocardiography and the incidence of ventricular remodeling were compared among the five groups. The correlation between the degree of ventricular remodeling and the levels of hs CRP and CysC in serum was analyzed. Results: The serum levels of Hs-CRP and CysC in the observation group were significantly higher than those in the control group, LVEDV and LVESV were higher and LVEF was lower than those in the control group (all P<0.05). Compared with group B, C and D, the levels of LVEDV and LVESV were higher, the incidence of ventricular remodeling was lower and the incidence of ventricular remodeling was higher in group A (all P<0.05). Compared with group D, the levels of LVEDV and LVESV in group B and C were higher, the LVEF was lower and the ventricular remodeling was lower. Incidence rate increased (P<0.05). Multivariate logistic regression analysis showed that elevated serum levels of Hs-CRP and CysC were independent predictors of ventricular remodeling after AMI (P<0.05). Conclusion: Serum levels of Hs-CRP and CysC are closely related to ventricular remodeling after AMI, and they are reliable indicators for predicting the degree of ventricular remodeling after AMI.
李霖, 刘劲, 黄创, 郭鹏, 陈艺钊, 林文培, 徐鸿远, 何媛, 刘海德. 急性心肌梗死后心室重构患者超敏C反应蛋白及胱抑素C检测的临床价值研究[J]. 河北医学, 2019, 25(12): 2045-2049.
LI Lin, LIU Jin, HUANG Chuang, et al. Clinical Value of Detection of High-sensitivity C-reactive Protein and Cystatin C in Patients with Ventricular Remodeling after Acute Myocardial Infarction. HeBei Med, 2019, 25(12): 2045-2049.
2019, Vol. 25 
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