Abstract：Objective: To analyze the effect of folic acid-assisted butylphthalide on patients with mild cognitive impairment. Methods: Eighty patients with mild cognitive dysfunction admitted to our hospital from June 2017 to January 2019 were enrolled in the observation group and the control group, 40 cases each. The control group was treated with butylphthalide, and the observation group was combined with folic acid treatment to compare the effects of the two groups on cognitive performance, mental state and adverse hair growth. Results: There was no significant difference in the MoCA scores between the two groups before treatment (P>0.05). The MoCA scores of the two groups increased in the first month and the second month after treatment, and the MoCA scores in the observation group were higher than those in the control group (P<0.05). There was no significant difference in the MMSE scores between the two groups (P>0.05). The MMSE scores were improved in both groups after 1 month and 2 months after treatment, and the scores of the observation group were higher than those in the control group (P<0.05). There was no significant difference between the amplitude and latency (P>0.05). After treatment, the amplitude of both groups increased and the latency decreased (P<0.05). The amplitude of the observation group was higher than that of the control group and the latency was lower than that of the control group (P< 0.05); The incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05). Conclusion: Folic acid-assisted butylphthalide treatment in MCI can effectively improve the mental state and cognitive function of patients, reduce the incidence of adverse reactions, and has high safety and is worthy of application.
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2019, Vol. 25 
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