Abstract：Objective: To investigate the effect of Sevelamer carbonate on microinflammation and prognosis in patients with chronic renal failure complicated with hyperphosphatemia, and to explore its microinflammation status and treatment measures. Methods: 80 patients with chronic renal failure complicated with hyperphosphorus were selected from August 2017 to August 2018 in our hospital. The patients were divided into observation group (40 cases) and control group (40 cases), according to the simple random grouping method. The control group was treated with calcium carbonate on the basis of routine hemodialysis, while the control group was treated with calcium carbonate on the basis of routine hemodialysis. Four weeks after treatment, the levels of TNF-alpha, CRP, IL-6, blood phosphorus, calcium and parathyroid hormone (iPTH) and the incidence of adverse reactions were compared between the two groups before and after treatment. Results: After treatment, the levels of TNF-a, CRP and IL-6 in the two groups were significantly lower than those before treatment, and the levels of each index in the observation group were significantly lower than those in the control group (P < 0.05); the levels of blood phosphorus, iPTH, calcium-phosphorus product in the two groups were significantly lower (P < 0.05), and the levels of each index in the observation group were significantly lower than those in the control group (P < 0.05). The difference was statistically significant (P < 0.05); the levels of serum calcium and bicarbonate in the two groups were significantly higher than those in the control group, and the level of bicarbonate in the control group was significantly lower than that in the observation group (P < 0.05); there was no statistical difference in the incidence of adverse events between the two groups (P < 0.05). Conclusion: Sevelamer carbonate can effectively reduce the level of inflammatory factors and regulate the level of blood phosphorus and calcium in patients with chronic renal failure combined with hyperphosphatemia, with good safety.
贺丹, 陆志峰, 陆静娟. 碳酸司维拉姆对慢性肾衰竭合并高磷血症患者微炎症状况及预后的影响[J]. 河北医学, 2019, 25(11): 1850-1854.
HE Dan, LU Zhifeng, LU Jingjuan. Effect of Sevelamer Carbonate on Microinflammation and Prognosis in Patients with Chronic Renal Failure Complicated with Hyperphosphatemia. HeBei Med, 2019, 25(11): 1850-1854.
2019, Vol. 25 
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