Abstract：Objective: To study effect of ulinastatin on inflammatory factors and coagulation function in patients with severe sepsis. Methods: 127 severe sepsis received therapy from February 2017 to February 2018 in our hospital were selected as research objects. According to the simple random grouping table, those patients were divided into the observation group (n=65) and the control group (n=62). The control group was treated with Xuebijing injection, while the observation group treated with Ulinastatin combined with Xuebijing injection. Then the Therapeutic efficacy, Interleukin-6 (IL-6), Interleukin-8 (IL-8), Tumor Necrosis Factor (TNF-alpha) levels, coagulation function indicators of platelet(PLT), fibrinogen (FIB), prothrombin time (PT) and activated partial thromboplastin time (APTT), Physiology and Chronic Health Score (APACHE II) Systemic Infection Related Organ Dysfunction Score (SOFA) of two groups after treatment were compared. Results: After treatment, The total effective rate of observation group was significantly higher than that of control group [92.30%(60/65)vs74.19%(46/62)](P＜0.05). The levels of IL-6, IL-8 and TNF-alpha in the control group were significantly lower than those in the control group [(24.86±3.12)ng/L vs(61.85±5.67)ng/L,(24.16±5.80)ng/L vs(51.79±10.73)ng/L,(85.16±11.10)g/L vs(116.98±13.67 g/L)](P＜0.05). PLT, FIB was significantly higher than that of control group [(122.56±19.42)×109/L vs(88.64±13.51)×109/L,(3.06±0.61)g/L vs(2.48±0.52)g/L](P＜0.05). PT, APTT were significantly lower than those in the control group [(12.98±3.21)s vs(16.30±3.26)s, (39.75±4.26)s vs(42.95±5.08)s](P＜0.05). APACHE II and SOFA scores were significantly lower than those of the control group [(12.98±2.41) scores vs(15.87±3.05)scores,(4.29±1.40)scores vs(5.98±1.62)scores](P＜0.05). Conclusion: Ulinastatin is effective in the treatment of severe sepsis. It can effectively relieve clinical symptoms, reduce the expression of inflammatory factors, regulate coagulation dysfunction, improve prognosis, and is safe and reliable.
骆黎, 毛光宇, 何海玲. 乌司他丁辅助治疗重度脓毒血症的疗效及对患者炎性因子凝血功能的影响[J]. 河北医学, 2019, 25(11): 1821-1825.
LUO Li, MAO Guangyu, HE Hailing. Effect of Ulinastatin on Inflammatory Factors and Coagulation Function in Patients with Severe Sepsis. HeBei Med, 2019, 25(11): 1821-1825.
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2019, Vol. 25 
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