[1] Chun J, Park M K, Ko H, et al. Bioassay-guided isolation of cantharidin from blister beetles and its anticancer activity through inhibition of epidermal growth factor receptor-mediated STAT3 and Akt pathways[J].Nat Med, 2018,72(4):937~945. [2] Liu Y P, Li L, Xu L, et al. Cantharidin suppresses cell growth and migration, and activates autophagy in human non-small cell lung cancer cells[J]. Oncol Lett, 2018,15(5):6527~6532. [3] Wang T, Liu J, Xiao X Q. Cantharidin inhibits angiogenesis by suppressing VEGF-induced JAK1/STAT3, ERK and AKT signaling pathways[J]. Arch Pharm Res, 2015,38(2):282~289. [4] Qiu L, Xu C, Jiang H, et al. Cantharidin Attenuates the Proliferation and Migration of Vascular Smooth Muscle Cells through Suppressing Inflammatory Response[J]. Biol Pharm Bull, 2019,42(1):34~42. [5] Xu M D, Liu S L, Zheng B B, et al. The radiotherapy-sensitization effect of cantharidin: Mechanisms involving cell cycle regulation, enhanced DNA damage, and inhibited DNA damage repair[J]. Pancreatology, 2018,18(7):822~832. [6] Koga Y, Tsurumaki H, Aoki-saito H, et al. Roles of cyclic AMP response element binding activation in the ERK1/2 and p38 MAPK signalling pathway in central nervous system, cardiovascular system, osteoclast differentiation and mucin and cytokine production[J]. Int J Mol Sci, 2019,20(6):E1346~E1369. [7] Liu H, Lin X, Huang T, et al. A short peptide reverses the aggressive phenotype of prostate cancer cells[J]. Eur Pharmacol, 2018,838(5):129~137. [8] Feng I C, Hsieh M J, Chen P N, et al. Cantharidic acid induces apoptosis through the p38 MAPK signaling pathway in human hepatocellular carcinoma[J]. Environ Toxicol, 2018,33(3):261~268. [9] Feng I C, Hsieh M J, Chen P N, et al. Cantharidic acid induces apoptosis through the p38 MAPK signaling pathway in human hepatocellular carcinoma[J]. Environ Toxicol, 2018,33(3):261~268. [10] Liu Y P, Li L, Xu L, et al. Cantharidin suppresses cell growth and migration, and activates autophagy in human non-small cell lung cancer cells[J]. Oncol Lett, 2018,15(5):6527~6532. [11] Wang T, Liu J, Xiao X Q. Cantharidin inhibits angiogenesis by suppressing VEGF-induced JAK1/STAT3, ERK and AKT signaling pathways[J]. Arch Pharm Res, 2015,38(2):282~289. [12] Zhang L, Ji Q, Liu X, et al. Norcantharidin inhibits tumor angiogenesis via blocking VEGFR2/MEK/ERK signaling pathways[J]. Cancer Sci, 2013,104(5):604~610. [13] Wu H, Fan F, Liu Z, et al. Norcantharidin combined with EGFR-TKIs overcomes HGF-induced resistance to EGFR-TKIs in EGFR mutant lung cancer cells via inhibition of Met/PI3k/Akt pathway[J]. Cancer Chemother Pharmacol, 2015,76(2):307~315. [14] Pires B, Silva R, Ferreira G M, et al. NF-kappaB: two sides of the same coin[J]. Genes (Basel), 2018,9(1):24~47. [15] Ji B C, Hsiao Y P, Tsai C H, et al. Cantharidin impairs cell migration and invasion of A375.S2 human melanoma cells by suppressing MMP-2 and -9 through PI3K/NF-kappaB signaling pathways[J]. Anticancer Res, 2015,35(2):729~738. [16] Jaeckel S, Kaller M, Jackstadt R, et al. Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells[J]. Nat Commun, 2018,9(1):3573~3590. [17] Li H C, Xia Z H, Chen Y F, et al. Cantharidin Inhibits the Growth of Triple-Negative Breast Cancer Cells by Suppressing Autophagy and Inducing Apoptosis in Vitro and in Vivo[J]. Cell Physiol Biochem, 2017,43(5):1829~1840. [18] Tao R, Sun W Y, Yu D H, et al. Sodium cantharidinate induces HepG2 cell apoptosis through LC3 autophagy pathway[J]. Oncol Rep, 2017,38(2):1233~1239. [19] 邱立强, 徐昌武, 李雯静, 等. 斑蝥素对血小板衍生生长因子BB诱导血管平滑肌细胞增殖和迁移的机制研究[J]. 中华老年心脑血管病杂志, 2019,21(1):58~62.