Abstract：Objective: To study the changes and significance of apolipoprotein(apo)A1/apoB and lipoprotein(Lp)(a) in patients with hypercholesterolemia. Methods: 150 patients with hypercholesterolemia received from January 2017 to November 2017 were selected as the observation group, and 150 healthy were selected in our hospital for the same period as the control group. All personnel were collected from fasting venous blood at 2d after admission, the expression of low density lipoprotein cholesterol (LDL-C), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), triglyceride (TG), apoA1, apoB, apoA1/apoB, Lp(a) were detected, to analyze the changes and significance of apoA1/apoB and Lp(a) in patients with hypercholesterolemia. Results: The LDL-C, TC, HDL-C, apoA1, apoB, apoA1/apoB and Lp(a) in the observation group were(5.71±0.36)mmol/L,(6.83±0.47)mmol/L,(1.04±0.07)mmol/L,(1.07±0.18)g/L,(1.07±0.23)g/L、(1.06±0.32), (258.18±20.95)mg/L respectively, in the control group were(1.78±0.12)mmol/L,(3.62±0.29)mmol/L,(1.34±0.07)mmol/L,(0.38±0.22)g/L,(0.84±0.08)g/L,(1.67±0.32),(154.82±17.49)mg/L respectively, the differences has statistically significant(P＜0.05); the Pearson correlation analysis showed that there was negatively correlated between apoA1/apoB and LDL-C and TC(r=-0.682, -0.679, P＜0.05), there was a positive correlation between Lp(a) and LDL-C and TC(r=0.926, 0.909, P＜0.05). Conclusion: There is obvious disorder of lipid metabolism in patients with hypercholesterolemia, and the decrease of apoA1/apoB and the increase of Lp (a) can reflect the disorder of lipid metabolism, this study also provides a new way for clinical treatment of hypercholesterolemia.
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2019, Vol. 25 
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