横向骨搬移技术联合PRP对糖尿病足溃疡患者修复效果及生活质量的影响

doi:10.3969/j.issn.1006-6233.2019.10.038

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摘要目的: 探讨横向骨搬移技术联合自体富血小板血浆对糖尿病足溃疡患者创面修复效果及生活质量影响。方法: 选取2018年1月至2018年10月我院收治并确诊糖尿病足患者134例,随机分为观察组与对照组,每组67例。对照组清创后以PRP外敷创面,观察组给以PRP外敷创面联合胫骨横向骨搬移术治疗。比较两组糖尿病足溃疡患者创面肉芽组织中血小板源性生长因子蛋白受体(PDGFR)的表达变化、创面缩小率、细菌清除率、肉芽组织覆盖率、肉芽组织厚度以及生活质量。结果: 治疗前,两组的PDGFR-α和PDGFR-β含量差异无统计学意义(P>0.05)。治疗后,两组的PDGFR-α和PDGFR-β含量较治疗前均增多,且观察组较对照组增多更为显著,差异有统计学意义(P<0.01)。观察组的创面缩小率明显大于对照组,细菌清除率及肉芽组织覆盖率显著高于对照组,以及肉芽组织生长厚度明显厚于对照组,差异均有统计学意义(P<0.01)。治疗后,两组的治疗影响、心理或精神、生理功能、社会关系4个维度分值均降低,且观察组的降低幅度大于对照组,差异有统计学意义(P<0.01)。结论: 横向骨搬移技术与PRP联合治疗DFU,可有效提高血小板源性生长因子蛋白受体表达,提高溃疡创面的修复效果,改善生活质量。

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关键词 ：糖尿病足溃疡, 横向骨搬移技术, 自体富血小板血浆, 修复效果, 生活质量

Abstract：Objective: To investigate the effect of transverse bone transfer technique combined with PRP on repairing effect and quality of life in patients with diabetic foot ulcer . Methods: 134 patients with diabetic foot from January 2018 to October 2018 were chosen and divided into observation group and control group , 67 cases in each group . The control group was treated with PRP topical wound after debridement , the observation group was treated with PRP external wound combined with transverse tibial bone transport . Compare the expression changes of PDGFR , wound reduction rate , bacterial clearance rate , granulation tissue coverage , granulation tissue thickness and quality of life between the two groups . Results: Before the treatment , there was no significant difference in PDGFR-α and PDGFR-β between the two groups ( P＞0.05 ) . After treatment , the levels of PDGFR-α and PDGFR-β in both groups were higher than before treatment , and the observation group increased more significantly than the control group , P＜0.01 . The rate of wound reduction in the observation group was significantly higher than that in the control group , the rate of bacterial clearance and the coverage rate of granulation tissue were significantly higher than that in the control group , and the growth thickness of granulation tissue was significantly thicker than that in the control group , P all ＜0.01 . After treatment , the scores of treatment influence , psychological or spiritual , physiological function , and social relationship of the two groups were reduced , and the reduction of the observation group was greater than that of the control group , P＜0.01 . Conclusion: Transverse-bone transfer technique combined with PRP in the treatment of DFU can effectively improve the expression of PDGFR , improve the repair effect of ulcer wounds , and improve the quality of life.

Key words： Diabetes foot ulcer Transverse bone transfer technique Platelet-rich plasma Repairing effect Quality of life

基金资助:河北省2018年度医学科学研究重点课题,(编号:20181050)

引用本文:

贺银习, 陈彦霞, 许英, 郭宇松, 田利军, 刘品力. 横向骨搬移技术联合PRP对糖尿病足溃疡患者修复效果及生活质量的影响[J]. 河北医学, 2019, 25(10): 1734-1736.
HE Yinxi, et al. Effect of Transverse Bone Transfer Technique Combined with PRP on Repairing Effect and Quality of Life in Patients with Diabetic Foot Ulcer. HeBei Med, 2019, 25(10): 1734-1736.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2019.10.038 或 http://www.hbyxzzs.cn/CN/Y2019/V25/I10/1734

[1] 李友山,杨博华.“蚓黄散”干预糖尿病足溃疡愈合过程中AGEs与促愈合因子相关性研究[J].世界科学技术-中医药现代化,2015,17(2):350~355.
[2] 冼呈,赵劲民,苏伟,等.胫骨横向骨搬移微循环再生技术治疗糖尿病足的临床疗效观察[J].广西医科大学学报,2015,32(4):605~607.
[3] 蒋丽艳,周苏键,刘文玉,等.高压氧对糖尿病足溃疡患者创面愈合、生活质量及负性情绪的影响[J].临床与病理杂志,2018,38(1):108~113.
[4] 刘艳萍,韩静,卢宝金,等.新型敷料对糖尿病足溃疡治疗效果的临床观察[J].河北医药,2018,40(11):1690~1693.
[5] 李彦辉,张嘉熙,宋少华,等.超声清创刀联合负压创面治疗糖尿病足溃疡的临床效果[J].重庆医学,2016,45(35):4986~4988,4991.
[6] 梁焯辉,赵凡,刘倩雯.负压封闭引流对糖尿病足肉芽组织PDGFR表达的影响及其临床意义[J].中国当代医药,2015,22(11):43~45.
[7] 陈诚,吴艳,陈琴.生肌玉红膏治疗糖尿病足溃疡的临床疗效及对创面组织内PDGFR-α表达的影响[J].中国美容医学,2018,27(9):58~61.
[8] 王斌,刘伟,霍永新,等.股-股动脉旁路移植联合胫骨横向骨搬移术治疗下肢动脉硬化闭塞症或合并糖尿病足[J].中国修复重建外科杂志,2018,32(12):1576~1580.
[9] 欧栓机,齐勇,孙鸿涛,等.经皮微创胫骨截骨横向骨搬移术治疗糖尿病足[J].中国矫形外科杂志,2018,26(15):1385~1389.
[10] 王林华,周富强,卢敏,等.应用Ilizarov横向骨搬移技术微创截骨治疗糖尿病足13例[J].中国中医骨伤科杂志,2018,26(11):42~45.
[11] 李立,柴益民.富血小板血浆促糖尿病创面愈合机制的初步研究[J].上海医学,2017,40(3):169~172.
[12] 张学成,孟凡军,战大川,等.自体富血小板血浆联合负压封闭引流在糖尿病足溃疡治疗中应用[J].临床军医杂志,2017,45(12):1261~1263.
[13] 陈德清,左国庆,朱丹平,等.自体富血小板凝胶治疗不同治疗周期中糖尿病足溃疡的临床评价[J].中国糖尿病杂志,2018,26(4):285~289.
[14] 付鹏,冯佳丽,苗婷,等.自体富血小板凝胶治疗对糖尿病足溃疡患者修复效果及生活质量的影响[J].解放军预防医学杂志,2018,36(7):858~861.