Abstract：Objective: To study the curative effect of mannitol combined with gamma globulin on children with severe hand, foot and mouth disease and the influence of white blood cell count and C reactive protein (CRP). Methods: 98 cases of hand, foot and mouth disease from February 2014 to February 2018 were selected. According to simple random grouping method, the children were divided into observation group (n=51) and control group (n=47). The control group was treated with gamma globulin, while the observation group was treated with mannitol combined with gamma globulin. The curative effect, clinical symptom subsidence time, white blood cell count, CRP level and the incidence of adverse reactions of the two groups were observed. Results: After treatment, the total effective rate of the observation group was significantly higher than that of the control group [94.11% (48/51) vs 74.46% (35/47)] (P<0.05), and the time of clinical symptoms subsidence was significantly lower than that of the control group [(2.18±0.63) D vs (4.01±0.85) d, (2.41 (+0.65) D vs (5.24 ±1.23) d, (2.90±0.52) D vs (5.86±1.30) d] (P < 0.05). The number and CRP were significantly lower than those of the control group [(10.36±4.62) 109/L vs (10.64±5.09) 109/L, (1.23±0.34) mg/L vs (2.97±0.75) mg/L] (P < 0.05), and the total incidence of adverse reactions was significantly lower than that of the control group [(5.88% (3/51) vs 21.27% (10/47)] (P<0.05). Conclusion: Mannitol combined with gamma globulin in the treatment of children with severe hand, foot and mouth disease has a significant effect. It can effectively improve the clinical symptoms of children with severe hand, foot and mouth disease, reduce the level of white blood cell count and CRP, and is safe and reliable.
高奎武, 王晨. 甘露醇联合丙种球蛋白对重症手足口病患儿的疗效观察及白细胞计数CRP的影响[J]. 河北医学, 2019, 25(10): 1651-1653.
GAO Kuiwu, WANG Chen. Effect of Mannitol combined with Gamma Globulin on Leukocyte count and CRP in Children with Severe Hand-foot-mouth Disease. HeBei Med, 2019, 25(10): 1651-1653.
[1] Upala P, Apidechkul T, Suttana W, et al. Molecular epidemiology and clinical features of hand, foot and mouth disease in northern Thailand in 2016: a prospective cohort study[J].BMC Infect Dis,2018, 18(1):630. [2] Hong Z, Hao H, Li C, et al. Exploration of potential risks of hand, foot and mouth disease in inner mongolia autonomous region, China using geographically weighted regression model[J].Sci Rep,2018, 8(1):17707. [3] 韦佩俭.手足口病临床防治研究进展[J].中国医学创新,2015,12(11):153~156. [4] 祁正红,邵启民.小剂量甲泼尼龙联合大剂量丙种球蛋白冲击治疗重症手足口病的疗效及对心肺功能的影响[J].儿科药学杂志,2015,21(4):20~23. [5] 张泽武,黄雪华,杨庆东,等.手足口病危险因素的meta分析[J].中国卫生统计,2015,32(01):112~114. [6] Chen Y, Badaruddin H, Lee VJ, et al. The effect of school closure on hand, foot and mouth disease transmission in singapore: a modeling approach[J].Am Trop Med Hyg,2018, 99(6):1625~1632. [7] 杨群燕,鲁月.干扰素、丙种球蛋白治疗手足口病合并病毒性脑炎的疗效及病情改善时间对比研究[J].中国生化药物杂志,2016,36(2):162~164. [8] Liang RX, Shi XY, Zhang YH, et al. Etiology and clinical analysis of central nervous system infection caused by Coxsackievirus B5 in severe hand, foot and mouth disease in Qingdao City, 2013-2014[J].Zhonghua Yu Fang Yi Xue Za Zhi,2018, 52(11):1168~1172. [9] 安庆玉,姚伟,吴隽,等.手足口病危险因素的Meta分析[J].中国卫生计,2013,30(4):576~578. [10] 徐小桥,金雅,黄磊瑛,等.甘露醇联合地塞米松治疗早期重症手足口病临床分析[J].现代医院,2015,15(11):55~56,58. [11] Wang XF, Lu J, Liu XX, et al. Epidemiological features of hand, foot and mouth disease outbreaks among Chinese preschool children: a meta-analysis[J].Iran Public Health,2018, 47(9):1234~1243.
2019, Vol. 25 
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