Abstract：Objective: To analyze the change of osteopontin (OPN) in type 2 diabetic (T2DM) patients with microangiopathy. Methods: 265 patients with type 2 diabetes mellitus (T2DM) were divided into simple type 2 diabetes mellitus (group A) 152 cases and microangiopathy group (group B) 113 cases. Eighty healthy volunteers who came to our hospital for physical examination were selected as control group (group N). The differences of OPN among the three groups were compared. The difference of serum OPN level between non-diabetic nephropathy group (NDN group) and diabetic nephropathy group (DN group) was compared. The difference of serum OPN level between non-diabetic retinopathy group (NDR group), non-proliferative phase group (NPDR group) and proliferative phase group (PDR group) was compared. Results: The level of OPN in group B was significantly higher than that in group A and group N (P < 0.05). The level of OPN in DN group was higher than that in NDN group, NPDR group was higher than that in NDR group, and PDR group was higher than that in NPDR group, with statistical significance (P < 0.05). Bivariate Logstic regression analysis showed that OPN was an independent risk factor for microangiopathy in patients with T2DM. ROC curve was used to evaluate the diagnostic value of serum OPN level in type 2 diabetes mellitus with microangiopathy, which was moderately predictive (AUC 0.787). Conclusion: Serum OPN level is correlated with the occurrence and severity of microangiopathy in patients with T2DM.
[1] Barrett EJ, Liu Z, Khamaisi M, et al. diabetic microvascular disease: an endocrine society scientific statement [J].Clin Endocrinol Metab, 2017, 102: 4343~4410. [2] Burhans MS, Hagman DK, Kuzma JN, et al. contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus [J]. Compr Physiol, 2018, 9(1):1~58. [3] Icer MA, Gezmen-Karadag M. the multiple functions and mechanisms of osteopontin [J]. Clin Biochem, 2018, 59:17~24. [4] Sharif S, Bots ML, Schalkwijk C, et al. association between bone metabolism regulators and arterial stiffness in type 2 diabetes patients [J]. Nutr Metab Cardiovasc Dis, 2018, 28:1245~1252. [5] Al-Malki AL. assessment of urinary osteopontin in association with podocyte for early predication of nephropathy in diabetic patients [J]. Dis Markers, 2014, 493736. [6] Abo El-Asrar M, Ismail EAR, Thabet RA, et al. osteopontin as a marker of vasculopathy in pediatric patients with type 1 diabetes mellitus: relation to vascular structure [J]. Pediatr Diabetes, 2018. [7] Rubsam A, Parikh S, Fort PE. role of inflammation in diabetic retinopathy [J]. Int Mol Sci, 2018: 19: 942~948. [8] Zhang X, Chee WK, Liu S, et al. association of plasma osteopontin with diabetic retinopathy in Asians with type 2 diabetes [J]. Mol Vis, 2018, 24: 165~173.
2019, Vol. 25 
冀公网安备13080202000677号