Abstract：Objective: To study the therapeutic effect of aripiprazole combined with sertraline on obsessive-compulsive disorder and effects of brain-derived neurotrophic factor, tumor necrosis factor (TNF) and interleukin-2 (IL-2). Methods: 82 received therapy from March 2017 to March 2018 in our hospital were selected as research objects. According to random number table,all the patients were divided into the observation group (n=42) and the control group (n=40). The control group was treated with Sertraline, while the observation group treated with Aripiprazole combined with sertraline. Then the Therapeutic efficacy, Yale Brown Obsessive-compulsive Disorder Scale (Y-BOCS) and Hamilton Anxiety Scale (HAMA) score, brain-derived neurotrophic factor, TNF, IL-2 level, incidence of adverse reactions of two groups after treatment were compared. Results: After treatment, The total effective rate of observation group was significantly higher than that of control group[92.85%(39/42)vs 70.00%(28/40)](P＜0.05).Y-BOCS and HAMA scores were significantly lower than those of the control group [(9.86±3.13)scores vs(14.42±4.52)scores,(7.68±2.10)scores vs(12.06±3.09)scores](P＜0.05). The levels of brain-derived neurotrophic factor and TNF were significantly higher than those of the control group [(40.02±5.87)μg/L vs(29.76±4.95)μg/L(38.49±8.98)μg/L vs(34.09±7.34)μg/L](P＜0.05). The level of IL-2 was significantly lower than that of the control group[(50.32±6.28)ng/L vs(62.93±7.59)ng/L](P＜0.05). Conclusion: Aripiprazole combined with sertraline is effective in the treatment of obsessive-compulsive disorder. It can improve the clinical symptoms, regulate the secretion of neurotransmitters in the brain, and improve the levels of brain-derived neurotrophic factor, TNF and IL-2. It is safe and reliable.
卜琴芳, 陈方斌. 阿立哌唑联合舍曲林治疗强迫症患者的疗效及对脑源性神经营养因子TNF IL-2水平的影响[J]. 河北医学, 2019, 25(10): 1589-1592.
BU Qinfang, CHEN Fangbin. Effect of Aripiprazole Combined with Sertraline on Obsessive-compulsive Disorder and Effects of Brain-derived Neurotrophic Factor TNF and IL-2. HeBei Med, 2019, 25(10): 1589-1592.
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2019, Vol. 25 
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