Abstract：Objective: To analyze the effect of premixed insulin combined with metformin on islet function recovery in newly diagnosed type 2 diabetes mellitus. Methods: 90 patients with newly diagnosed type 2 diabetes who according to simple random number table method were divided into 48 control group and 42 research group. The control group was treated with metformin, and the research group was treated with premixed insulin based on the control group. Then blood glucose compliance time, blood glucose metabolism indicators, islet function, liver and kidney function before and after treatment after 8 weeks and 12 weeks after treatment, and adverse reaction in both group were compared. Results: blood glucose compliance time of research group was higher than that in the control group (7.41±1.02) and (11.78±1.90) days (P<0.05). After 8 weeks and 12 weeks treatment, the blood glucose metabolism indexes in both groups was decreased, and the research group was lower than the control group (P<0.05). The fasting insulin (FINS), insulin resistance index (HOMA-IR) in research group were lower than the control group, while the islet beta cell function (HOMA-β) was higher than the control group, there was a statistically significant difference (P<0.05). liver and kidney function before and after treatment in both group was no statistically significant difference (P>0.05). Both groups had hypoglycemia and gastrointestinal reactions, the incidence of total adverse reactions in both groups was no statistically significant difference (P>0.05). Conclusion: Insulin pretreatment combined with metformin is effective and safe for the new diagnosis of type 2 diabetes, which can effectively control blood glucose and promote the recovery of insulin function.
刘佳, 崔旭红, 王丽艳, 徐以康. 预混胰岛素联合二甲双胍对新诊断2型糖尿病患者胰岛功能恢复的影响[J]. 河北医学, 2019, 25(1): 18-21.
LIU Jia, CUI Xuhong, WANG Liyan, et al. Effects of Premixed Insulin Combined with Metformin on Islet function Recovery in Newly Diagnosed Type 2 Diabetes Mellitus. HeBei Med, 2019, 25(1): 18-21.
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2019, Vol. 25 
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