Abstract：Objective: To study the clinical efficacy of edaravone combined with vinpocetine injection in the treatment of acute cerebral hemorrhage and its effect on neurological function. Methods: A total of 86 patients who underwent acute cerebral hemorrhage in our hospital from March 2015 to March 2018 were selected,they were randomly divided into observation group (43 cases) and control group (43 cases). All the patients were given routine treatment, the control group was given vinpocetine injection , the observation group was combined with edaravone. NIH Stroke Scale (NIHSS) score, clinical efficacy, neuron-specific enolated alcohol (NSE), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) were compared between two groups. Results: After 2 weeks and after 4 weeks of treatment, The NIHSS score in the observation groups was lower than that of the control group [(11.87 ± 1.22)points, (7.12 ± 0.73)points VS(14.98 ± 1.43)points, (10.98 ± 1.26)points] (P<0.05). After treatment, the total effective rate of the observation group was higher than that of the control group [83.72% (36/43) VS 65.11% (28/43)] (P<0.05). The levels of NSE, TNF-α and IL-6 in the observation group were lower than those in the control group [(8.54±0.76) ug/L,(14.87±1.34) ng/L,(32.54±3.17) ng/L VS (19.43±1.53) ug/L,(24.32±2.76 )ng/L,(47.65±4.22) ng/L] (P<0.05). Conclusion: Acute cerebral hemorrhage using edaravone combined with vinpocetine injection, can effectively improve the patient's neurological function, clinical efficacy is good.
高守君, 李婧, 吴艺, 高敏. 依达拉奉联合长春西汀注射液治疗急性脑出血的临床研究及对神经功能的影响[J]. 河北医学, 2019, 25(1): 123-126.
GAO Shoujun, et al. Clinical Study of Edaravone combined with Vinpocetine Injection in the treatment of Acute Cerebral Hemorrhage and its effect on Neurological Function. HeBei Med, 2019, 25(1): 123-126.
[1] Lorenz MW , Lauer A , Foerch C . Quantifying the benefit of prehospital rapid treatment in acute stroke: benchmark for future innovative clinical trials[J]. Stroke, 2015, 46 (11 ):3168~3176. [2] 田自有,陈赛贞,徐利君,等.依达拉奉联合丹红注射液治疗急性脑梗死疗效的系统分析[J].中国实验方剂学杂志,2015,21(20):218~224. [3] 王忠诚.神经外科学[M].武汉:湖北科学技术出版社,2012.279,326. [4] 陈清棠.脑卒中患者神经功能缺损评分标准[J].中华神经科杂志,1996,29(6):381. [5] 张建林,郑利敏,袁中瑞,等.神经节苷脂对急性脑出血患者神经功能缺损程度及日常生活活动能力的影响[J].中国生化药物杂志,2014,12(5):104~105. [6] Sato S , Carcel C , Anderson CS . Blood pressure management after intracerebral hemorrhage[J]. Current treatment options in neurology, 2015, 17 (12 ):49. [7] 周云建.急性脑梗死应用长春西汀治疗效果的临床观察[J].中国医院药学杂志,2013,33(19):1608~1610. [8] Mao Y , Nan GX , Zhang L ,et al. Contrast extravasation mimics cerebral hemorrhage in acute ischemic stroke after Solitaire FR clot retrieval and intraarterial thrombolysis: a case report[J]. Acta neurologica Belgica, 2015,115 (4 ):723~725.
2019, Vol. 25 
冀公网安备13080202000677号