Abstract：Objective: To explore the feasibility of predicting early hematoma enlargement in intracerebral hemorrhage (ICH) with serum cholesterol and matrix metalloproteinase-9 (MMP-9). Methods: From November 2015 to December 2017, all ICH cases in neurosurgery department of our hospital were sorted out and classified. 162 patients who met the exclusion criteria were selected and grouped according to the results of CT examination at admission and 24 hours after admission. There were 114 patients in group A without bleeding and 48 patients in group B with rebleeding. The levels of TC, HDL-C, LDL-C and MMP-9 in serum of all patients in the two groups were compared and analyzed. Results: The serum TC content (6.02±0.53) mmol/L and LDL-C (3.43±0.88) mmol/L were significantly higher in group A than in group B (4.11±0.38) mmol/L and LDL-C. The content was (2.12±0.49) mmol/L (P<0.05); while in Group A, the serum HDL-C (1.01±0.25) mmol/L and MMP-9 (97.6±36.1) mmol/L were significant. There was a statistically significant difference between the two groups in terms of the content of HDL-C (1.98±0.41) mmol/L and MMP-9 (127.6±31.5) mmol/L in the B group (P<0.01). Conclusion: The combination of serum cholesterol (TC, HDL-C, LDL-C) and MMP-9 levels may have a predictive effect on the early hematoma volume changes in ICH, which can provide new ideas for the treatment of early ICH. It is of significance to the prognosis of this disease.
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2019, Vol. 25 
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