Curative Efficacy of Bipolar Radiofrequency Discectomy in Treatment of Cervical Intervertebral Disc Protrusion and Effects on Serum IL-1β TNF-α and TXB2 Levels
MA Bo, ZHANG Ning, GAO Yang, et al
The First Hospital of Yulin, Shaanxi Yulin 719000, China
Abstract：Objective: To investigate the effect of bipolar radiofrequency disc nucleoplasty on the clinical efficacy of cervical disc herniation and the effects on serum levels of interleukins (IL-1 beta), tumor necrosis factor (TNF- alpha) and thromboxane (TXB2) in patients. Methods: The clinical data of 96 cases of cervical disc herniation in our hospital from Dec. 2014 to Dec. 2016 were retrospectively analyzed. 48 cases of single stage radiofrequency were used as a single stage group and 48 patients with bipolar radiofrequency were used as a bipolar group. The monopole group was protrused RF needle at the base of the protrusion, while the bipolar group was protrused base is sandwiched between the two needle operating ends, the distance between two electrodes and tips should less than 0.8cm. The visual analogue scale (VAS), serum IL-1β, TNF-α, TXB2 and JOA scores before and after the operation, clinical efficacy and incidence of postoperative complications were compared between two groups. Results: On the 7th, 14th day after operation, the VAS score and serum IL-1β, TNF-α and TXB2 levels of both groups were significantly lower than those before operation (P<0.05), and the VAS score, serum IL-1β, TNF-α and TXB2 levels of bipolar group were significantly lower than those of the monopole group on the 7th, 14th day after operation (P<0.05); On the 14th, 30th day after operation, the JOA scores of both groups were significantly increased compared with those before treatment (P<0.05), and the JOA scores of bipolar group were significantly lower than those of the monopole group on the 14th, 30th day after operation (P<0.05); the excellent and good rate of bipolar group was significantly higher than that of the monopole group (P<0.05); there was no significant difference in the incidence of postoperative complications between the two groups (P＞0.05). Conclusion: Bipolar radiofrequency discectomy is prominently effective for cervical intervertebral disc protrusion, which can relieve the postoperative pain and improve the function of cervical spine, its intrinsic mechanism may be related to the decrease of serum IL-1β, TNF-α, TXB2 expression.
2018, Vol. 24 
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