Abstract：Objective: To compare the clinical efficacy of combined ureteroscopic lithotripsy with holmium laser lithotripsy and percutaneous nephrolithotomy in the treatment of renal calculi. Methods: 102 patients with renal calculi from March 2016 to August 2017 in our hospital were divided into observation group (n=51) and control group (n=51) according to different surgical methods. The control group was treated with percutaneous nephrolithotomy, and the observation group was treated by combined ureteroscope and holmium laser lithotripsy. The recovery of surgery and postoperative were compared between the two groups including (operation time, intraoperative bleeding, stone clearance rate, hospitalization time), preoperative and postoperative 72h oxidative damage index malondialdehyde (MDA), superoxide dismutase (SOD), the occurrence rate of complications and quality of life score of 3 months before and after operation. Results: Operation and postoperative recovery: There was no significant difference between the two groups of operation, 96.08% (49/51) and 94.12% (48/51)) (P > 0.05). Compared with the control group, the amount of bleeding in the observation group was less and the time of hospitalization was shorter (P < 0.05). Oxidative stress injury: There was no significant difference in serum MDA and SOD levels between the observation group and the control group before operation (P > 0.05), and 72 h after operation. The level of serum MDA in the observation group was lower than that of the control group, and the level of SOD was higher than that of the control group (P < 0.05). Complications: The incidence of postoperative complications in the observation group was 1.96% (1/51), which was lower than that in the control group (15.69%) (8/51), and the difference was statistically significant (P < 0.05). Quality of life: There was no significant difference in the quality of life between the two group before operation (P>0.05); After 3 months, the quality of life score of the observation group was higher than that of the control group(P<0.05). Conclusion: Combined ureteroscopic lithotripsy with holmium laser lithotripsy and percutaneous nephrolithotomy in the treatment of renal calculi can achieve the ideal effect of gravel, but the former than the latter to the body smaller damage, less bleeding and lighter oxidative stress response, lower complication rate, which is conducive to the early rehabilitation of patients.
陈晨, 王臣, 李子良, 鲁可权. 组合式输尿管软镜联合钬激光碎石术与经皮肾镜碎石术治疗肾结石对比研究[J]. 河北医学, 2018, 24(8): 1358-1361.
CHEN Chen, WANG Chen, LI Ziliang, et al. Comparative Study of Combined Ureteroscopic Flexible Holmium Laser Lithotripsy and Percutaneous Nephrolithotomy in the treatment of Renal Calculi. HeBei Med, 2018, 24(8): 1358-1361.
2018, Vol. 24 
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