Abstract：Objective: To investigate the curative effect of metformin combined with da-35 on polycystic ovary syndrome in women of childbearing age. Methods: 70 women of childbearing age who were admitted to hospital from January 2015 to June 2017 were randomly divided into two groups: metformin in the single drug group and up to Ying-35 in the combined group Disease-related parameters in two groups of patients, overall treatment effect, BBT biphasic rate, pregnancy outcome and safety. Results: BMI (23.40 ± 0.82), average follicular volume (7.01 ± 0.50), mean antral follicle count (5.05 ± 0.73), FINS (17.38 ± 2.75), Homa-IR (2.96 ± 0.50), LH ± 0.73), LH / FSH (0.71 ± 0.19) and TG (115.56 ± 25.18) were significantly lower than those in the single drug group (24.47 ± 0.80,7.94 ± 0.58,6.35 ± 0.90,19.41 ± 2.60,3.76 ± 0.61,6.09 ± 1.03,1.09 ± 0.20,130.44 ± 23.78), intima thickness (9.70 ± 1.09), FSH (12.36 ± 2.48) and HDL-C (72.48 ± 9.31) were significantly higher than those in the single drug group (7.07 (94.29%), bipolar rate of BBT (62.86%), ovulation (88.57%) and pregnancy rate (77.14%) were significantly different between the two groups ) Were significantly higher in single drug group (74.29%, 34.29%, 68.57%, 51.43%), there was a significant difference (P <0.05). There was no significant difference between the two groups in the adverse drug reaction rate (17.14% vs. 5.71%) (P> 0.05). Conclusion: Metformin combined with dimethyl -35 is effective and safe in the treatment of polycystic ovary syndrome in women of childbearing age.
周立红, 玛娜尔·朱马汗, 鲁春雁. 二甲双胍联合达英-35治疗育龄期妇女多囊卵巢综合征的疗效观察[J]. 河北医学, 2018, 24(8): 1351-1353.
ZHOU Lihong, MANAER·Zhumahan, LU Chunyan. Observation of the Effect of Metformin combined with Dimethyl -35 in the treatment of Polycystic Ovary Syndrome in Women of Childbearing Age. HeBei Med, 2018, 24(8): 1351-1353.
[1] Sam S,Ehrmann D A.Metformin therapy for the reproductive and metabolic consequences of polycystic ovary syndrome[J].Diabetologia,2017,60(9):1656~1661. [2] 郑海珍,陈彩飞.达英-35、二甲双胍联合克罗米芬治疗多囊卵巢综合征不孕患者的临床疗效[J].中国妇幼保健,2010,25(30):4431~4433. [3] 裴慧琳.达英-35和二甲双胍对多囊卵巢综合征患者性激素水平及胰岛素抵抗的影响[J].中国医药导报,2013,10(1):73~75. [4] 黄剑兰.达英-35和二甲双胍对多囊卵巢综合征患者性激素水平及胰岛素抵抗的影响观察[J].现代中西医结合杂志,2013,22(25):2775~2777. [5] Tomczyk R,Ociepka A,Kialka M,et al.Metformin and changes in blood pressure and heart rate in lean patients with polycystic ovary syndrome(PCOS)--preliminary study[J].Przegl Lek,2015,72(6):302~305. [6] Pourmatroud E,Mohammadjafari R,Roozitalab M.Comparison of metformin and simvastatin administration in women with polycystic ovary syndrome before intra-cytoplasmic sperm injection cycle:a prospective,randomized, clinical trial study[J].Iran Red Crescent Med,2015,17(12):e20082. [7] 侯莲云,闫胜英.达英-35联合二甲双胍治疗多囊卵巢综合征后促排卵效果观察[J].中国计划生育学杂志,2010,18(7):429~431. [8] Kalem M N,Kalem Z,Gurgan T.Effect of metformin and oral contraceptives on polycystic ovary syndrome and IVF cycles[J].Endocrinol Invest,2017,40(7):745~752.
2018, Vol. 24 
冀公网安备13080202000677号