Effects of Standard Large Trauma Craniotomy combined with Mild Hypothermia on Postoperative NIHSS Score and Serum S-00β and MBP Levels in Patients after Operation with Severe Craniocerebral Injury
FENG Tao, HAN Bing, YE Kaihua
The Second People's Hospital of Dongying, Shandong Dongying 257335, China
Abstract：Objective: To investigate the effects of standard large trauma craniotomy combined with mild hypothermia on postoperative NIHSS score and serum astrocyte protein (S-100β) and myelin basic protein (MBP) in patients with severe craniocerebral injury. Methods: From April 2016 to November 2017, 72 patients with severe craniocerebral injury were treated in the Department of Neurosurgery at the second people's Hospital in Dongying. The random digital table method was divided into the control group (n=36) and the study group (n=36). The control group was treated with standard large trauma craniotomy, while the study group was treated with standard large trauma craniotomy plus mild hypothermia treatment. 1 month after admission and 1 month after operation, the scores of two groups of nerve function defect (NIHSS), intracranial pressure level (1d, 2d, 3d), and the changes of serum S-100 beta and MBP levels at admission and first d after operation were compared, and the incidence of complications in two groups were compared. Results: The NIHSS scores in the two groups after treatment were lower than those before treatment, and the study group was lower than the control group, the difference was statistically significant (P <0.05); The intracranial pressure of the two groups at 1d, 2d and 3d after treatment was lower than before treatment, and the study group was lower than that of the control group at each time period, the difference was statistically significant (P <0.05); The levels of serum S-100β and MBP in the two groups after treatment were lower than those before treatment, the study group was lower than the control group, the difference was statistically significant (P <0.05); The incidence of complications in the study group was significantly lower than that of the control group (P <0.05). Conclusion: Treatment of severe craniocerebral injury using standard large trauma craniotomy combined with mild hypothermia gets a significant effect, which can effectively reduce intracranial pressure, improve neurological function, reduce serum S-100β, MBP levels, and the low incidence of complications , with higher security, worthy of promotion.
冯涛, 韩兵, 叶凯华. 标准外伤大骨瓣开颅术联合亚低温对重型颅脑损伤患者术后NIHSS评分及血清S-100β MBP水平的影响[J]. 河北医学, 2018, 24(8): 1325-1328.
FENG Tao, HAN Bing, YE Kaihua. Effects of Standard Large Trauma Craniotomy combined with Mild Hypothermia on Postoperative NIHSS Score and Serum S-00β and MBP Levels in Patients after Operation with Severe Craniocerebral Injury. HeBei Med, 2018, 24(8): 1325-1328.
2018, Vol. 24 
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