地塞米松联合熊脱氧胆酸治疗妊娠期肝内胆汁淤积的临床疗效及对血清PLTP IL-18水平的影响

doi:10.3969/j.issn.1006-6233.2018.08.006

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摘要 目的: 研究地塞米松联合熊脱氧胆酸对妊娠期肝内胆汁淤积症患者的临床疗效。 方法: 选择2014年10月至2016年10月在我院进行治疗的妊娠期肝内胆汁淤积症患者130例,按照治疗方法不同分为观察组和对照组,观察组给予地塞米松联合熊脱氧胆酸治疗,对照组给予地塞米松治疗。比较两组的临床治疗效果、治疗前后肝功能指标、血清PLTP、IL-18水平、瘙痒评分的变化及妊娠结局。 结果: 治疗后,观察组总有效率(93.8%)明显高于对照组(80.0%)(P<0.05);观察组血清PLTP、IL-18水平均明显低于对照组[(3.17±0.33)pg/mL vs. (4.47±0.49)pg/mL;(58.03±6.02)ng/mL vs. (68.86±7.11)ng/mL](P<0.05),且血清TBA、ALT、AST、TBIL水平、瘙痒评分、剖宫产率均明显的低于对照组(P<0.05),早产率、胎儿窘迫率、新生儿窒息率均低于对照组,但差异无统计学意义(P>0.05),Apgar评分明显高于对照组(P<0.05)。 结论: 地塞米松联合熊脱氧胆酸治疗妊娠期肝内胆汁淤积症的临床疗效显著优于单用地塞米松治疗,可有效改善患者肝功能和妊娠结局,并降低血清PLTP、IL-18水平。

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关键词 ：妊娠期肝内胆汁淤积症, 地塞米松, 熊脱氧胆酸

Abstract：Objective: To study curative efficacy of dexamethasone combined with ursodeoxycholic acid in treatment of intrahepatic cholestasis of pregnancy and its effects on level of PLTP,IL-18. Methods: 130 patients with intrahepatic cholestasis of pregnancy treated in our hospital from Oct. 2014 to Oct. 2016 were selected and divided into the observation group and the control group according to different treatment methods. The patients in observation group were treated with dexamethasone and deoxycholic acid, while the patients in control group were treated with dexamethasone. Then the clinical effect, serum levels of PLTP and IL-18, pruritus score and pregnancy outcomes in the two groups were observed and compared before and after the treatment. Results: After treatment, the total efficacy of observation group was 93.8%, which was obviously higher than that of the control group (80.0%, P<0.05); After treatment, the serum levels of PLTP and IL-18 in the observation group were significantly lower than those of the control group (3.17±0.33) pg/mL vs (4.47±0.49) pg/mL; (58.03±6.02) ng/mL vs (68.86±7.11) ng/mL)(P<0.05); After treatment, the levels of ALT, AST and TBIL, and pruritus score of observation group were significantly lower than those of the control group(P<0.05). There was no statistically significant difference in the incidence of premature birth, fetal distress and neonatal asphyxia between the two groups (P>0.05). The cesarean section rate in the observation group was significantly lower than that of the control group, and the apgar score was higher (P<0.05). Conclusion: The clinical efficacy of dexamethasone combined with ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy is significantly better than that of dexamethasone alone. It can effectively improve the liver function and pregnancy outcome, and reduce the level of serum PLTP and IL-18.

Key words： Intrahepatic cholestasis of pregnancy Dexamethasone Ursodeoxycholic acid

基金资助:陕西省自然科学基金项目,(编号:2009Jm³013)

通讯作者: 黄娟娟

引用本文:

李华, 张利平, 高霞, 王娟, 黄娟娟. 地塞米松联合熊脱氧胆酸治疗妊娠期肝内胆汁淤积的临床疗效及对血清PLTP IL-18水平的影响[J]. 河北医学, 2018, 24(8): 1254-1257.
LI Hua, ZHANG Liping, GAO Xia, et al. Efficacy of Dexamethasone combined with Ursodeoxycholic Acid in Clinical treatment of Intrahepatic Cholestasis of Pregnancy and its Effects on Level of PLTP IL-18. HeBei Med, 2018, 24(8): 1254-1257.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2018.08.006 或 http://www.hbyxzzs.cn/CN/Y2018/V24/I8/1254

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