Abstract：Objective: To evaluate the pharmacoeconomic efficacy of two kinds of regimens used in outpatient department of our hospital for the treatment of insomnia, and to provide an objective basis for the rational use of insomnia in treating patients with insomnia. Methods: According to guidelines for the diagnosis and treatment of adult insomnia in China, the patients were randomly divided into two groups, a group of treatment group with Zolpidem Tartrate tablets 10mg/d, and a group of control group with Alprazolam 0.4mg/d. After seven-days administration before going to sleep, efficacy evaluation and the rate of adverse effect of the use of SDRS score were compared. And the cost effectiveness was analyzed. Results: The effective rate of the two groups respective were 77.78%,73.81%;The effective rate had no significant difference between two groups(P＞0.05); Adverse drug reaction had no significant difference between two groups(P＞0.05);The average cost in the Zolpidem Tartrate tablets group was 23.9 yuan, and the Alprazolam group was 0.63 yuan. Sensitivity analysis revealed that the results were not sensitive to changes in the drug cost. Conclusion: Both Zolpidem Tartrate tablets and Alprazolam tablets are available for insomnia, but more advantage of Alprazolam tablets in the cost-effectiveness.
2018, Vol. 24 
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