Abstract:Objective: To investigate the relationship between neutrophil lymphocyte ratio,coronary artery disease and Gensini score. Methods: Patients were divided into coronary artery disease (CAD) group (123 cases) and Non-CAD group (60 cases) according to coronary angiography (CAG) results.The baseline data and blood biochemical data of all patients were collected.NLR and Gensini score were calculated and the relationship of them were analyzed. Results: The NLR were higher in CAD group (3.55±1.56) compared with Non-CAD group (2.41±0.90) (P<0.001) .Multivariate Logistic regression analysis showed that NLR (OR = 2.752, 95% CI:1.729-4.38) was an independent risk factors of CAD.The Pearson regression analysis showed that it was a positive correlation between Gensini score and NLR (r =0.426, P < 0.001). Conclusion:The level of NLR was closely related to CAD and correlated with the Gensini score representing the degree of coronary stenosis.
董文超, 王瑞鹃, 严亚琪, 李硕, 单伟超, 丁振江. 中性粒细胞/淋巴细胞比值与冠心病及Gensini评分的相关性研究[J]. 河北医学, 2018, 24(6): 997-1000.
DONG Wenchao, WANG Ruijuan, YAN Yaqi, et al. Study on the Relationship Among Neutrophil Lymphocyte Ratio, Coronary Artery Disease and Gensini Score. HeBei Med, 2018, 24(6): 997-1000.
[1] 国家卫生计生委合理用药专家委员会,中国药师协会.《冠心病合理用药指南》[J].中国医学前沿杂志,2016,8(6):19~108. [2] Shah N,Parikh V,Patel N,et a1.Neutrophil lymphocyte ratio significantly improves the Framingham risk score in prediction of coronary heart disease mortality: Insights from the National Health and Nutrition Examination Survey-III[J].Int J Cardiol,2014,171(3):390~397. [3] Abdulkadir Yildiz,Mehmet Ata Akil,Fethullah Kayan,et a1.Assessment of neutrophil / lymphocyte ratio in patients with myocardial bridge[J].Journal of Clinical and Experimental Investigations. 2014,5(5):24~28. [4] Liu LP,Cheng K,Ning MA,et a1.Association between peripheral blood cells mitochondrial DNA content and severity of coronary heart disease[J].Atherosclerosis ,2017,261:105~110. [5] GENSINI GG.A more meaningful scoring system for determining the severity of coronary heart disease [J]. Am Cardiol,1983, 51(3):606. [6] Sam Cheol Kim,Kyung-Hoon Sun,Dong-Hyun Choi,et a1.Prediction of long-term mortality based on neutrophil-lymphocyte ratio after percutaneous coronary intervention[J].The American Journal of the Medical Sciences, 2016 ,351(5):467~472. [7] Kurtul, Alparslan,Yarlioglues, et a1.Association of neutrophil-to-lymphocyte ratio with contrast-induced nephropathy in patients with non-ST-elevation acute coronary syndrome treated with percutaneous coronary intervention.[J].Heart Lung Circ, 2016,25(7):683~690. [8] Yu C,Chen M,Chen Z,et a1.Predictive and prognostic value of admission neutrophil-to-lymphocyte ratio in patients with CHD[J].Herz, 2016,41(7):605~613. [9] Kadir Uysal,Turkoglu,Yildiray Sahin,et a1.The relationship between neutrophil-to-lymphocyte ratio and coronary collateral circulation[J].Clinical & Applied Thrombosis/Hemostasis, 2015,21(4):329~333. [10] Kurtul S,Sarli B,Baktir AO,et a1.Neutrophil to lymphocyte ratio predicts SYNTAX score in patients with non-ST segmentelevation myocardial infarction[J].Int Heart, 2015,56(1):18~21 [11] Zhang GY,Chen M,Yu ZM,et a1. Relation between neutrophil-to-lymphocyte ratio and severity of coronary artery stenosis [J].Genetics And Molecular Research,2014,13(4):9382~9389. [12] Verdoia M,Schaffer A,Barbieri L,et a1.Impact of diabetes on neutrophil-to-lymphocyte ratio and its relationship to coronary artery disease[J].Diabetes Metab, 2015,41(4):304~311. [13] Teague H,Mehta NN.The link between inflammatory disorders and coronary heart disease: a look at recent studies and novel drugs in development[J].Curr Atheroscler Rep, 2016,18(1):3. [14] Taleb S.Inflammation in atherosclerosis[J].Arch Cardiovasc Dis,2016,109(12):708~715.